Hepatitis C virus (HCV) can cause liver disease of variable severity. Expansion of preexisting memory CD8 T cells by cross-reactivity with a new heterologous virus infection has been shown in mice to shape the repertoire of the primary response and to influence virus-related immunopathology (Selin, L.K. 2004. Immunity. 20:5-16). To determine whether this mechanism can influence the course of HCV infection, we analyzed the features of the HCV-specific CD8 T cell response in eight patients with acute HCV infection, two of whom had a particularly severe illness. Patients with severe hepatitis, but not those with mild disease, showed an extremely vigorous CD8 T cell response narrowly focused on a single epitope (NS3 1073-1081), which cross-reacted with an influenza neuraminidase sequence. Our results suggest that CD8 T cell cross-reactivity influences the severity of the HCV-associated liver pathology and depicts a model of disease induction that may apply to different viral infections. © The Rockefeller University Press.

Heterologous T cell immunity in severe hepatitis C virus infection / Urbani, Simona; Amadei, Barbara; Fisicaro, Paola; Pilli, Massimo; Missale, Gabriele; Bertoletti, Antonio; Ferrari, Carlo. - In: JOURNAL OF EXPERIMENTAL MEDICINE. - ISSN 0022-1007. - 201:5(2005), pp. 675-680. [10.1084/jem.20041058]

Heterologous T cell immunity in severe hepatitis C virus infection

Missale, Gabriele;FERRARI, Carlo
2005

Abstract

Hepatitis C virus (HCV) can cause liver disease of variable severity. Expansion of preexisting memory CD8 T cells by cross-reactivity with a new heterologous virus infection has been shown in mice to shape the repertoire of the primary response and to influence virus-related immunopathology (Selin, L.K. 2004. Immunity. 20:5-16). To determine whether this mechanism can influence the course of HCV infection, we analyzed the features of the HCV-specific CD8 T cell response in eight patients with acute HCV infection, two of whom had a particularly severe illness. Patients with severe hepatitis, but not those with mild disease, showed an extremely vigorous CD8 T cell response narrowly focused on a single epitope (NS3 1073-1081), which cross-reacted with an influenza neuraminidase sequence. Our results suggest that CD8 T cell cross-reactivity influences the severity of the HCV-associated liver pathology and depicts a model of disease induction that may apply to different viral infections. © The Rockefeller University Press.
Heterologous T cell immunity in severe hepatitis C virus infection / Urbani, Simona; Amadei, Barbara; Fisicaro, Paola; Pilli, Massimo; Missale, Gabriele; Bertoletti, Antonio; Ferrari, Carlo. - In: JOURNAL OF EXPERIMENTAL MEDICINE. - ISSN 0022-1007. - 201:5(2005), pp. 675-680. [10.1084/jem.20041058]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2815053
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