Hepatitis C virus (HCV)-specific CD8 cell exhaustion may represent a mechanism of HCV persistence. The inhibitory receptor PD-1 has been reported to be up-regulated in exhausted CD8 cells. Therefore, we studied PD-1 expression longitudinally during acute HCV infection. Most HCV-specific CDS cells expressed PD-1 at the time of acute illness, irrespective of the final outcome. PD-1 expression declined with the acquisition of a memory phenotype and recovery of an efficient CDS cell function in resolving HCV infections, whereas high levels were maintained when HCV persisted and HCV-specific CDS cells remained dysfunctional. Blocking PD-1/PDL-1 interaction with an anti-PDL-1 antibody improved the capacity of expansion of virus-specific CD8 cells. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion / Urbani, Simona; Amadei, Barbara; Tola, Daniela; Massari, Marco; Schivazappa, Simona; Missale, Gabriele; Ferrari, Carlo. - In: JOURNAL OF VIROLOGY. - ISSN 0022-538X. - 80:22(2006), pp. 11398-11403. [10.1128/JVI.01177-06]

PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion

Missale, Gabriele;FERRARI, Carlo
2006-01-01

Abstract

Hepatitis C virus (HCV)-specific CD8 cell exhaustion may represent a mechanism of HCV persistence. The inhibitory receptor PD-1 has been reported to be up-regulated in exhausted CD8 cells. Therefore, we studied PD-1 expression longitudinally during acute HCV infection. Most HCV-specific CDS cells expressed PD-1 at the time of acute illness, irrespective of the final outcome. PD-1 expression declined with the acquisition of a memory phenotype and recovery of an efficient CDS cell function in resolving HCV infections, whereas high levels were maintained when HCV persisted and HCV-specific CDS cells remained dysfunctional. Blocking PD-1/PDL-1 interaction with an anti-PDL-1 antibody improved the capacity of expansion of virus-specific CD8 cells. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion / Urbani, Simona; Amadei, Barbara; Tola, Daniela; Massari, Marco; Schivazappa, Simona; Missale, Gabriele; Ferrari, Carlo. - In: JOURNAL OF VIROLOGY. - ISSN 0022-538X. - 80:22(2006), pp. 11398-11403. [10.1128/JVI.01177-06]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2814929
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