Repertoire composition, quantity, and qualitative functional ability are the parameters that define virus-specific T-cell responses and are linked with their potential to control infection. We took advantage of the segregation of different hepatitis B virus (HBV) genotypes in geographically and genetically distinct host populations to directly analyze the impact that host and virus variables exert on these virus-specific T-cell parameters. T-cell responses against the entire HBV proteome were analyzed in a total of 109 HBV-infected subjects of distinct ethnicities (47 of Chinese origin and 62 of Caucasian origin). We demonstrate that HBV-specific T-cell quantity is determined by the virological and clinical profiles of the patients, which outweigh any influence of race or viral diversity. In contrast, HBV-specific T-cell repertoires are divergent in the two ethnic groups, with T-cell epitopes frequently found in Caucasian patients seldom detected in Chinese patients. In conclusion, we provide a direct biological evaluation of the impact that host and virus variables exert on virus-specific T-cell responses. The discordance between HBV-specific CD8 T-cell repertoires present in Caucasian and Chinese subjects shows the ability of HLA micropolymorphisms to diversify T-cell responses and has implications for the rational development of therapeutic and prophylactic vaccines for worldwide use. Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire / Tan, Anthony Oto; Loggi, Elisabetta; Boni, Carolina; Chia, Adeline; Gehring, Adam J.; Sastry, Konduru S. R.; Goh, Vera; Fisicaro, Paola; Andreone, Pietro; Brander, Christian; Seng, Gee Lim; Ferrari, Carlo; Bihl, Florian; Bertoletti, Antonio. - In: JOURNAL OF VIROLOGY. - ISSN 0022-538X. - 82:22(2008), pp. 10986-10997. [10.1128/JVI.01124-08]

Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire

Boni, Carolina;FERRARI, Carlo;
2008-01-01

Abstract

Repertoire composition, quantity, and qualitative functional ability are the parameters that define virus-specific T-cell responses and are linked with their potential to control infection. We took advantage of the segregation of different hepatitis B virus (HBV) genotypes in geographically and genetically distinct host populations to directly analyze the impact that host and virus variables exert on these virus-specific T-cell parameters. T-cell responses against the entire HBV proteome were analyzed in a total of 109 HBV-infected subjects of distinct ethnicities (47 of Chinese origin and 62 of Caucasian origin). We demonstrate that HBV-specific T-cell quantity is determined by the virological and clinical profiles of the patients, which outweigh any influence of race or viral diversity. In contrast, HBV-specific T-cell repertoires are divergent in the two ethnic groups, with T-cell epitopes frequently found in Caucasian patients seldom detected in Chinese patients. In conclusion, we provide a direct biological evaluation of the impact that host and virus variables exert on virus-specific T-cell responses. The discordance between HBV-specific CD8 T-cell repertoires present in Caucasian and Chinese subjects shows the ability of HLA micropolymorphisms to diversify T-cell responses and has implications for the rational development of therapeutic and prophylactic vaccines for worldwide use. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
2008
Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire / Tan, Anthony Oto; Loggi, Elisabetta; Boni, Carolina; Chia, Adeline; Gehring, Adam J.; Sastry, Konduru S. R.; Goh, Vera; Fisicaro, Paola; Andreone, Pietro; Brander, Christian; Seng, Gee Lim; Ferrari, Carlo; Bihl, Florian; Bertoletti, Antonio. - In: JOURNAL OF VIROLOGY. - ISSN 0022-538X. - 82:22(2008), pp. 10986-10997. [10.1128/JVI.01124-08]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2814918
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