The aim of the study was to evaluate the characteristics of chronic hepatitis B with special reference to the geographical origin of the patients and to the prevalence of HBeAg and viral and non-viral co-factors of liver disease. A cross sectional multicenter survey was undertaken, which enrolled 1,386 HBsAg chronic carriers observed consecutively in 21 referral centers over a 6-month period. The prevalence of HBeAg in patients was 11%; the presence of HBeAg was associated independently with a younger age and co-infection with HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected in 8.1%, 6.5%, and 2%, respectively. However, among the patients first diagnosed during the study period (incident cases), 14.3% were anti-HDV positive. Seven percent of the patients were immigrants; they were younger than Italian patients and 18% were HBeAg positive; no difference was observed in the prevalence of anti-HDV, anti-HCV, or anti-HIV antibodies. The presence of cirrhosis was associated independently with an age >52 years, the presence of anti-HDV or anti-HCV, alcohol use >4 drinks/day, and a high BMI. The clinical epidemiology of chronic hepatitis B virus (HBV) infection shows a dynamic profile, with the potential for re-emergence of cases with HBeAg or anti-HDV and an emerging impact of metabolic factors on the evolution of liver disease. © 2009 Wiley-Liss, Inc.
Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study / Stroffolini, Tommaso; Almasio, Piero L.; Sagnelli, Evangelista; Mele, Alfonso; Gaeta, Giovanni Battista; Andreone, Pietro; Scuteri, Alessandra; Antonucci, Giorgio; Iacomi, Fabio; Babudieri, Sergio; Pintus, Antonio; Stornaiuolo, Gianfranca; Brancaccio, Giuseppina; Brunetto, Maurizia; Sasso, Rodolfo; Caporaso, Nicola; Morisco, Filomena; Chiaramonte, Maria; Lattanzi, Emiliano; Di Marco, Vito; Venezia, Giovanna; Fagiuoli, Stefano; Boninsegna, Sara; Fattovich, Giovanna; Olivari, Nicola; Ferrari, Carlo; Giuberti, Tiziana; Ferrigno, Luigina; Magnani, Giacomo; Massari, Marco; Mangano, Carmelo; Caserta, Carmelo; Messina, Vincenzo; Pastore, Giuseppe; Palattella, Stefania; Piccinino, Felice; Stanzione, Maria; Pinzello, Giovanbattista; Vinci, Maria; Raimondo, Giovanni; Caccamo, Gaia; Roffi, Luigi; Bellia, Valentina; Rizzetto, Mario; Smedile, Antonina; Ciancio, Alessia. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 81:12(2009), pp. 1999-2006. [10.1002/jmv.21643]
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