Herpesviruses infect most humans. Their infections can be associated with pathological conditions and significant changes in T cell repertoire but evidences of symbiotic effects of herpesvirus latency have never been demonstrated. We tested the hypothesis that HCMV and EBV-specific CD8 T cells contribute to the heterologous anti-viral immune response. Volume of activated/proliferating virus-specific and total CD8 T cells was evaluated in 50 patients with acute viral infections: 20 with HBV, 12 with Dengue, 12 with Influenza, 3 with Adenovirus infection and 3 with fevers of unknown etiology. Virus-specific (EBV, HCMV, Influenza) pentamer+ and total CD8 T cells were analyzed for activation (CD38/HLA-DR), proliferation (Ki- 7/Bcl- 2low) and cytokine production. We observed that all acute viral infections trigger an expansion of activated/proliferating CD8 T cells, which differs in size depending on the infection but is invariably inflated by CD8 T cells specific for persistent herpesviruses (HCMV/EBV). CD8 T cells specific for other non-related non persistent viral infection (i.e. Influenza) were not activated. IL-15, which is produced during acute viral infections, is the likely contributing mechanism driving the selective activation of herpesvirus specific CD8 T cells. In addition we were able to show that herpesvirus specific CD8 T cells displayed an increased ability to produce the anti-viral cytokine interferon-c during the acute phase of heterologous viral infection. Taken together, these data demonstrated that activated herpesvirus specific CD8 T cells inflate the activated/ proliferating CD8 T cells population present during acute viral infections in human and can contribute to the heterologous anti-viral T cell response. © 2010 Sandalova et al.
Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans / Sandalova, Elena; Laccabue, Diletta; Boni, Carolina; Tan, Anthony T.; Fink, Katja; Ooi, Eng Eong; Chua, Robert; Schreve, Bahar Shafaeddin; Ferrari, Carlo; Bertoletti, Antonio. - In: PLOS PATHOGENS. - ISSN 1553-7366. - 6:8(2010), pp. 47-48. [10.1371/journal.ppat.1001051]
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