Processing and presentation by T cells appear to be limited to antigens that can directly interact with the T-cell surface, thereby overcoming the T-cell inefficiency in antigen capture and internalization. Our study provides evidence that the hepatitis B virus (HBV) envelope proteins can also be efficiently processed and presented by CD4+ and CD8+ T cells to other T cells in a human leukocyte antigen class II-restricted fashion. This phenomenon suggests a receptor-mediated interaction between T cells and the HBV envelope and defines a system that can, we hope, be exploited for the identification of the receptor binding site within the HBV envelope and for the characterization of the putative cellular HBV receptor.

Autopresentation of hepatitis B virus envelope antigens by T cells / Ferrari, C; Pilli, M; Penna, A; Bertoletti, A; Valli, A; Cavalli, A; Pasetti, G; Fiaccadori, F. - In: JOURNAL OF VIROLOGY. - ISSN 0022-538X. - 66:4(1992), p. 2536-40.

Autopresentation of hepatitis B virus envelope antigens by T cells

FERRARI, Carlo;
1992

Abstract

Processing and presentation by T cells appear to be limited to antigens that can directly interact with the T-cell surface, thereby overcoming the T-cell inefficiency in antigen capture and internalization. Our study provides evidence that the hepatitis B virus (HBV) envelope proteins can also be efficiently processed and presented by CD4+ and CD8+ T cells to other T cells in a human leukocyte antigen class II-restricted fashion. This phenomenon suggests a receptor-mediated interaction between T cells and the HBV envelope and defines a system that can, we hope, be exploited for the identification of the receptor binding site within the HBV envelope and for the characterization of the putative cellular HBV receptor.
Autopresentation of hepatitis B virus envelope antigens by T cells / Ferrari, C; Pilli, M; Penna, A; Bertoletti, A; Valli, A; Cavalli, A; Pasetti, G; Fiaccadori, F. - In: JOURNAL OF VIROLOGY. - ISSN 0022-538X. - 66:4(1992), p. 2536-40.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2814012
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