A simple and versatile microwave-assisted protocol for the synthesis of 2-aminothiazoles has been developed. The domino reac- tion of propargylamines and isothiocyanates in the presence of catalyt- ic PTSA leads to the selective synthesis of 2-aminothiazoles at tempera- tures above 130 °C and in a few minutes. The same reaction carried out at lower temperatures leads to the formation of the tautomeric 2-ami- no-4-methylenethiazolines.
Microwave assisted domino reactions of propargylamines with isothiocyanates: selective synthesis of 2-aminothiazoles and 2-amino-4-methylenethiazolines / Scalacci, Nicolò; Pelloja, Chiara; Radi, Marco; Castagnolo, Daniele. - In: SYNLETT. - ISSN 0936-5214. - 27:(2016), pp. 1883-1887. [10.1055/s-0035-1561985]
Microwave assisted domino reactions of propargylamines with isothiocyanates: selective synthesis of 2-aminothiazoles and 2-amino-4-methylenethiazolines
RADI, Marco;
2016-01-01
Abstract
A simple and versatile microwave-assisted protocol for the synthesis of 2-aminothiazoles has been developed. The domino reac- tion of propargylamines and isothiocyanates in the presence of catalyt- ic PTSA leads to the selective synthesis of 2-aminothiazoles at tempera- tures above 130 °C and in a few minutes. The same reaction carried out at lower temperatures leads to the formation of the tautomeric 2-ami- no-4-methylenethiazolines.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
