A low radiation dose approach to cell eradication would be highly desirable in cancer treatments in order to reduce the side ellects of conventional radiotherapy. In the present work we present a preliminary study on coltures of bone marrow mononuclear cells collected from normal subjects and patients with chronic myelogenous leukaemia (CML). Hematin (104, 10-3, 10°M) has been added to mattow culture cells which were then irradiated with a 3.7 GBq (100 mCi)57Co/Rh Mossbauer source for 4 hours. Significant inbibition has been observed on the cell growth due to hematin and irradiatron. © 1992 J.C. Baltzer A.G., Scientific Publishing Company.
Effects of Mössbauer radiation on bone marrow cultures / Ortalli, Ida; Pedrazzi, Giuseppe; Jiang, K.; Zhang, X.; Carlo Stella, C.; Mangoni, Marcellina; Rizzoli, Vittorio. - In: HYPERFINE INTERACTIONS. - ISSN 0304-3843. - 71:1-4(1992), pp. 1267-1270. [10.1007/BF02397314]
Effects of Mössbauer radiation on bone marrow cultures
ORTALLI, Ida;PEDRAZZI, Giuseppe;MANGONI, Marcellina;RIZZOLI, Vittorio
1992-01-01
Abstract
A low radiation dose approach to cell eradication would be highly desirable in cancer treatments in order to reduce the side ellects of conventional radiotherapy. In the present work we present a preliminary study on coltures of bone marrow mononuclear cells collected from normal subjects and patients with chronic myelogenous leukaemia (CML). Hematin (104, 10-3, 10°M) has been added to mattow culture cells which were then irradiated with a 3.7 GBq (100 mCi)57Co/Rh Mossbauer source for 4 hours. Significant inbibition has been observed on the cell growth due to hematin and irradiatron. © 1992 J.C. Baltzer A.G., Scientific Publishing Company.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
