Introduction: Mean age at diagnosis for incidental gallbladder cancer (IGC) has been increasing over time. Purpose of our study was to reassess our IGC cohort regarding implemented treatments, especially investigating the late age burden over potential therapeutic options. Materials and methods: 7841 cholecystectomies performed in a single center between 2002 and 2013 were retrospectively collected. Patients with IGC were identified and demographics, type of surgery, stage, survival, morbidity and mortality were analyzed. Results: 49 patients (0.62%) had IGC (63% female, 18% male). Average age at diagnosis was 76 years. 10 patients were T1a, 11 were T1b, 16 were T2, 8 were T3 and 4 were T4. None of the T1a patients was reoperated or had tumor recurrence at the latest follow-up. Only 11 of 39 patients (28%) with advanced stage were suitable for surgery and SIV b + SV bisegmentectomy with or without major bile duct resection was carried out. Radical surgery was precluded mainly for late age and comorbidities (16 patients), 5 patients were unresectable, 4 refused surgery and 3 were lost during follow-up. T1b and T2 patients had no recurrence after radical resection. Conclusions: IGC presented at late age in our cohort, spread over an 11-year period. Most series reported an average age at diagnosis lower than 70 years. The majority of patients did not receive a stepwise surgical approach due to age-related issues or because they refused surgery for late age. Subsequent radical resection provided excellent outcomes for those submitted to surgery at early stages.

INCIDENTAL GALLBLADDER CARCINOMA. IS POOR PROGNOSIS RELATED TO LATE AGE OF PRESENTATION? / Dalla Valle, R.; Lamecchi, L.; Perrone, G.; Pellegrino, C.; Iaria, M.. - In: HPB. - ISSN 1477-2574. - 18(s1)(2016), pp. 474-474.

INCIDENTAL GALLBLADDER CARCINOMA. IS POOR PROGNOSIS RELATED TO LATE AGE OF PRESENTATION?

DALLA VALLE, Raffaele;LAMECCHI, Laura;PERRONE, Gennaro;PELLEGRINO, CARLO;
2016

Abstract

Introduction: Mean age at diagnosis for incidental gallbladder cancer (IGC) has been increasing over time. Purpose of our study was to reassess our IGC cohort regarding implemented treatments, especially investigating the late age burden over potential therapeutic options. Materials and methods: 7841 cholecystectomies performed in a single center between 2002 and 2013 were retrospectively collected. Patients with IGC were identified and demographics, type of surgery, stage, survival, morbidity and mortality were analyzed. Results: 49 patients (0.62%) had IGC (63% female, 18% male). Average age at diagnosis was 76 years. 10 patients were T1a, 11 were T1b, 16 were T2, 8 were T3 and 4 were T4. None of the T1a patients was reoperated or had tumor recurrence at the latest follow-up. Only 11 of 39 patients (28%) with advanced stage were suitable for surgery and SIV b + SV bisegmentectomy with or without major bile duct resection was carried out. Radical surgery was precluded mainly for late age and comorbidities (16 patients), 5 patients were unresectable, 4 refused surgery and 3 were lost during follow-up. T1b and T2 patients had no recurrence after radical resection. Conclusions: IGC presented at late age in our cohort, spread over an 11-year period. Most series reported an average age at diagnosis lower than 70 years. The majority of patients did not receive a stepwise surgical approach due to age-related issues or because they refused surgery for late age. Subsequent radical resection provided excellent outcomes for those submitted to surgery at early stages.
INCIDENTAL GALLBLADDER CARCINOMA. IS POOR PROGNOSIS RELATED TO LATE AGE OF PRESENTATION? / Dalla Valle, R.; Lamecchi, L.; Perrone, G.; Pellegrino, C.; Iaria, M.. - In: HPB. - ISSN 1477-2574. - 18(s1)(2016), pp. 474-474.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2808256
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