Uncertainty model of electro-optical thrombus growth estimation for early risk detection

It is proposed a device for the study of the real-time aggregation of white thrombi in whole blood. This device allows extrapolating the 3D-shape of platelets clotting within artificial capillaries, by simultaneously monitoring the electrical impedance between a pair of specifically designed gold electrodes and 2D optical image of pixel luminance of the fluorescent labeled platelets. Up to 30 3D images per minute have been obtained, for a process which requires few minutes before the aggregation of large thrombi structures, a noticeable result with respect to other 3D-shape reconstruction methods. The contribution of this paper mainly consists in the study of an uncertainty model which, in our opinion, is of fundamental importance to provide a valuable metrological estimation of thrombus growth under flow conditions.