It is proposed a device for the study of the real-time aggregation of white thrombi in whole blood. This device allows extrapolating the 3D-shape of platelets clotting within artificial capillaries, by simultaneously monitoring the electrical impedance between a pair of specifically designed gold electrodes and 2D optical image of pixel luminance of the fluorescent labeled platelets. Up to 30 3D images per minute have been obtained, for a process which requires few minutes before the aggregation of large thrombi structures, a noticeable result with respect to other 3D-shape reconstruction methods. The contribution of this paper mainly consists in the study of an uncertainty model which, in our opinion, is of fundamental importance to provide a valuable metrological estimation of thrombus growth under flow conditions.
Uncertainty model of electro-optical thrombus growth estimation for early risk detection / Affanni, A; Chiorboli, G.; Specogna, R.; Trevisan, F.. - In: MEASUREMENT. - ISSN 0263-2241. - 79(2016), pp. 260-266. [10.1016/j.measurement.2015.05.045]
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