Human cytomegalovirus (HCMV) is still considered to be the main viral cause of birth defects and long-term neurological and sensory sequelae following congenital infection. Several Authors sustain a key role of HCMV envelope glycoproteins, such as gB, gN and gO - mainly involved in cell targeting, viral penetration and spread - as putative virulence factors. The genes coding for these glycoproteins possess hypervariable regions, resulting in a number of genetic variants in circulating clinical strains. Considering that the genetic polymorphisms underlying the specific differences between gB, gN and gO genotypes can influence the ability of HCMV to preferentially target specific host cells, it is very likely that they play an important role in defining HCMV infection outcome. In the present study, we analysed HCMV gB, gN and gO gene polymorphisms in viral strains isolated from paediatric patients with congenital or post-natal infection, to investigate whether specific genetic variants may be associated with congenital infection.

Combined genetic variants of human cytomegalovirus envelope glycoproteins as congenital infection markers / Arcangeletti, Maria Cristina; VASILE SIMONE, Rosita; Rodighiero, Isabella; DE CONTO, Flora; Medici, Maria Cristina; Martorana, Davide; Chezzi, Carlo; Calderaro, Adriana. - In: VIROLOGY JOURNAL. - ISSN 1743-422X. - 12:1(2015), p. 202. [10.1186/s12985-015-0428-8]

Combined genetic variants of human cytomegalovirus envelope glycoproteins as congenital infection markers

ARCANGELETTI, Maria Cristina;VASILE SIMONE, Rosita;RODIGHIERO, Isabella;DE CONTO, Flora;MEDICI, Maria Cristina;MARTORANA, DAVIDE;CHEZZI, Carlo;CALDERARO, Adriana
2015-01-01

Abstract

Human cytomegalovirus (HCMV) is still considered to be the main viral cause of birth defects and long-term neurological and sensory sequelae following congenital infection. Several Authors sustain a key role of HCMV envelope glycoproteins, such as gB, gN and gO - mainly involved in cell targeting, viral penetration and spread - as putative virulence factors. The genes coding for these glycoproteins possess hypervariable regions, resulting in a number of genetic variants in circulating clinical strains. Considering that the genetic polymorphisms underlying the specific differences between gB, gN and gO genotypes can influence the ability of HCMV to preferentially target specific host cells, it is very likely that they play an important role in defining HCMV infection outcome. In the present study, we analysed HCMV gB, gN and gO gene polymorphisms in viral strains isolated from paediatric patients with congenital or post-natal infection, to investigate whether specific genetic variants may be associated with congenital infection.
2015
Combined genetic variants of human cytomegalovirus envelope glycoproteins as congenital infection markers / Arcangeletti, Maria Cristina; VASILE SIMONE, Rosita; Rodighiero, Isabella; DE CONTO, Flora; Medici, Maria Cristina; Martorana, Davide; Chezzi, Carlo; Calderaro, Adriana. - In: VIROLOGY JOURNAL. - ISSN 1743-422X. - 12:1(2015), p. 202. [10.1186/s12985-015-0428-8]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2799059
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