Melatonin is a neurohormone involved in the regulation of circadian rhythms, with potent antioxidant activity. It has a wide functional repertoire, with effects almost on all tissues and organs. It is mainly used as a dietary supplement for sleep regulation and re-synchronization of disrupted circadian rhythms. Melatonin has very low toxicity, but some pharmacokinetic issues, such as limited oral bioavailability and short half-life, limit its tissue availability.
Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012 - 2014) / Rivara, Silvia; Pala, Daniele; Bedini, Annalida; Spadoni, Gilberto. - In: EXPERT OPINION ON THERAPEUTIC PATENTS. - ISSN 1354-3776. - 25:4(2015), pp. 425-441. [10.1517/13543776.2014.1001739]
Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012 - 2014)
RIVARA, Silvia;PALA, Daniele;
2015-01-01
Abstract
Melatonin is a neurohormone involved in the regulation of circadian rhythms, with potent antioxidant activity. It has a wide functional repertoire, with effects almost on all tissues and organs. It is mainly used as a dietary supplement for sleep regulation and re-synchronization of disrupted circadian rhythms. Melatonin has very low toxicity, but some pharmacokinetic issues, such as limited oral bioavailability and short half-life, limit its tissue availability.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
