Diabetic cardiomyopathy (DCM) develops independently of common cardiovascular comorbidities and is initiated by the metabolic derangements accompanying diabetes mellitus, including hyperglycaemia, which may cause a mild inflammatory state able to negatively affect myocardial biochemistry, structure, and function. This work shows how different urolithins, ellagitannin-derived metabolites, were able to modulate the pro-inflammatory mediators and growth factors secreted by rat cardiac myocytes and fibroblasts exposed to high glucose concentrations. At 1 M concentration, coherent with dietary exposure to ellagitannin-rich foods, urolithins B and B-glucuronide succeeded in preventing inflammatory responses in cardiomyocytes, while in fibroblasts urolithin D was the most effective in controlling the overexpression of fractalkine, among the tested inflammatory mediators. Urolithins underwent extensive biotransformations in both cell types, including (de)glucuronidation, methylation, and sulphation. This suggests that the inflammatory bulk produced by hyperglycaemia could be attenuated by the regular intake of ellagitannin-rich foodstuffs such as pomegranates, raspberries, blackberries, strawberries, and walnuts.

Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions / Sala, Roberto; MENA PARRENO, Pedro Miguel; Savi, Monia; Brighenti, Furio; Crozier, Alan; Miragoli, Michele; Stilli, Donatella; DEL RIO, Daniele. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 15:(2015), pp. 97-105. [10.1016/j.jff.2015.03.019]

Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions

SALA, Roberto;MENA PARRENO, Pedro Miguel;SAVI, Monia;BRIGHENTI, Furio;MIRAGOLI, MICHELE;STILLI, Donatella;DEL RIO, Daniele
2015

Abstract

Diabetic cardiomyopathy (DCM) develops independently of common cardiovascular comorbidities and is initiated by the metabolic derangements accompanying diabetes mellitus, including hyperglycaemia, which may cause a mild inflammatory state able to negatively affect myocardial biochemistry, structure, and function. This work shows how different urolithins, ellagitannin-derived metabolites, were able to modulate the pro-inflammatory mediators and growth factors secreted by rat cardiac myocytes and fibroblasts exposed to high glucose concentrations. At 1 M concentration, coherent with dietary exposure to ellagitannin-rich foods, urolithins B and B-glucuronide succeeded in preventing inflammatory responses in cardiomyocytes, while in fibroblasts urolithin D was the most effective in controlling the overexpression of fractalkine, among the tested inflammatory mediators. Urolithins underwent extensive biotransformations in both cell types, including (de)glucuronidation, methylation, and sulphation. This suggests that the inflammatory bulk produced by hyperglycaemia could be attenuated by the regular intake of ellagitannin-rich foodstuffs such as pomegranates, raspberries, blackberries, strawberries, and walnuts.
Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions / Sala, Roberto; MENA PARRENO, Pedro Miguel; Savi, Monia; Brighenti, Furio; Crozier, Alan; Miragoli, Michele; Stilli, Donatella; DEL RIO, Daniele. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 15:(2015), pp. 97-105. [10.1016/j.jff.2015.03.019]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2787091
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