1,3-Oxazolindin-2-one derivatives were obtained for the first time through carboxylative cyclization of allylamines in the absence of any metal or base catalyst. An electron-withdrawing substituent on the allylic double bond is crucial for the reaction success. Allylamines react with CO2 in MeCN/MeOH mixture and in scCO2 giving satisfactory results.
A novel one-pot synthesis of oxazolidinones through direct introduction of CO2 into allylamine derivatives / Soldi, Laura; Massera, Chiara; Costa, Mirco; DELLA CA', Nicola. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 55:7(2014), pp. 1379-1383. [10.1016/j.tetlet.2014.01.029]
A novel one-pot synthesis of oxazolidinones through direct introduction of CO2 into allylamine derivatives
SOLDI, Laura;MASSERA, Chiara;COSTA, Mirco;DELLA CA', Nicola
2014-01-01
Abstract
1,3-Oxazolindin-2-one derivatives were obtained for the first time through carboxylative cyclization of allylamines in the absence of any metal or base catalyst. An electron-withdrawing substituent on the allylic double bond is crucial for the reaction success. Allylamines react with CO2 in MeCN/MeOH mixture and in scCO2 giving satisfactory results.| File | Dimensione | Formato | |
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