The aim of this paper is to present a novel inversion technique to measure the volume of thrombus induced under blood flow conditions in a lab-on-a-chip device. The device is composed by a microscope slide where gold electrodes are sputtered and by a polydimethylsiloxane microchannel placed on the top of the slide. A thrombogenic substance is placed on the slide in such a way that hemostasis is induced when whole blood flows in the microchannel. The novel idea behind the inversion technique is to fuse optical and electrical impedance data to obtain a quasi-real-time reconstruction of thrombus volume. This is not possible with present state-of-the-art optical imaging based on confocal microscopy, which provides the thrombus volume estimation only at the end of the thrombus formation.

A Novel Inversion Technique for Imaging Thrombus Volume in Microchannels Fusing Optical and Impedance Data / A., Affanni; Chiorboli, Giovanni; L., Codecasa; M. R., Cozzi; L., De Marco; M., Mazzucato; Morandi, Carlo; R., Specogna; M., Tartagni; F., Trevisan. - In: IEEE TRANSACTIONS ON MAGNETICS. - ISSN 0018-9464. - 50:2(2014), pp. 1021-1024. [10.1109/TMAG.2013.2281987]

A Novel Inversion Technique for Imaging Thrombus Volume in Microchannels Fusing Optical and Impedance Data

CHIORBOLI, Giovanni;MORANDI, Carlo;
2014-01-01

Abstract

The aim of this paper is to present a novel inversion technique to measure the volume of thrombus induced under blood flow conditions in a lab-on-a-chip device. The device is composed by a microscope slide where gold electrodes are sputtered and by a polydimethylsiloxane microchannel placed on the top of the slide. A thrombogenic substance is placed on the slide in such a way that hemostasis is induced when whole blood flows in the microchannel. The novel idea behind the inversion technique is to fuse optical and electrical impedance data to obtain a quasi-real-time reconstruction of thrombus volume. This is not possible with present state-of-the-art optical imaging based on confocal microscopy, which provides the thrombus volume estimation only at the end of the thrombus formation.
2014
A Novel Inversion Technique for Imaging Thrombus Volume in Microchannels Fusing Optical and Impedance Data / A., Affanni; Chiorboli, Giovanni; L., Codecasa; M. R., Cozzi; L., De Marco; M., Mazzucato; Morandi, Carlo; R., Specogna; M., Tartagni; F., Trevisan. - In: IEEE TRANSACTIONS ON MAGNETICS. - ISSN 0018-9464. - 50:2(2014), pp. 1021-1024. [10.1109/TMAG.2013.2281987]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2688495
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