The emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) bacteria has become a medical and veterinary problem. Antimicrobial peptides (AMPs) show potential to overcome antibiotic resistance and could be used therapeutically. A novel AMP (AMP2041) was developed in silico and its microbiocidal activity against MDR clinical strains isolated from cattle (n=6), dogs (n=8), and pigs (n=20) was evaluated. AMP2041 showed strong antimicrobial activity against all Gram-positive and Gram-negative MDR clinical strains tested. Within 20min of incubation, there was complete killing of Pseudomonas aeruginosa ATCC 27953 and a 90% reduction of colony count for Escherichia coli ATCC 25922. For Staphylococcus aureus ATCC 25923, a 90% reduction of colony count was observed within 120min of incubation

Broad-spectrum activity of a novel antibiotic peptide against multidrug-resistant veterinary isolates / Cabassi, Clotilde Silvia; Taddei, Simone; Cavirani, Sandro; Baroni, Maria Cristina; Sansoni, Paolo; Romani, A. A.. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 198:(2013), pp. 534-537. [10.1016/j.tvjl.2013.08.020]

Broad-spectrum activity of a novel antibiotic peptide against multidrug-resistant veterinary isolates

CABASSI, Clotilde Silvia;TADDEI, Simone;CAVIRANI, Sandro;BARONI, Maria Cristina;SANSONI, Paolo;
2013-01-01

Abstract

The emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) bacteria has become a medical and veterinary problem. Antimicrobial peptides (AMPs) show potential to overcome antibiotic resistance and could be used therapeutically. A novel AMP (AMP2041) was developed in silico and its microbiocidal activity against MDR clinical strains isolated from cattle (n=6), dogs (n=8), and pigs (n=20) was evaluated. AMP2041 showed strong antimicrobial activity against all Gram-positive and Gram-negative MDR clinical strains tested. Within 20min of incubation, there was complete killing of Pseudomonas aeruginosa ATCC 27953 and a 90% reduction of colony count for Escherichia coli ATCC 25922. For Staphylococcus aureus ATCC 25923, a 90% reduction of colony count was observed within 120min of incubation
Broad-spectrum activity of a novel antibiotic peptide against multidrug-resistant veterinary isolates / Cabassi, Clotilde Silvia; Taddei, Simone; Cavirani, Sandro; Baroni, Maria Cristina; Sansoni, Paolo; Romani, A. A.. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 198:(2013), pp. 534-537. [10.1016/j.tvjl.2013.08.020]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2644062
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