OBJECTIVE: The aim of this study was to identify the correlation between antinuclear antibody (ANA) titre and the onset and clinical course of uveitis in children with juvenile idiopathic arthritis (JIA) or without any other systemic autoimmune disease, i.e., idiopathic uveitis (IU). METHODS: Twenty-two patients affected by uveitis were examined. Ten had JIA-associated uveitis, 12 had IU. Follow-up ranged from 7 to 101 months. The ANA were titrated three times per year and additionally in case of ocular recurrences. All patients were treated with immunosuppressive drug combination therapy (IDCT). RESULTS: JIA-associated uveitis: ocular recurrences were noted in three ANA-positive patients and in one ANA-negative patient. IU uveitis: ocular recurrences were noted in one ANA-positive and in one ANA-negative patient. No significant rise in ANA titre was noted in either group during uveitis recurrence.
Autoimmune uveitis in children: clinical correlation between antinuclear antibody positivity and ocular recurrences / Manzotti, Francesca; Orsoni, Gabriella; Zavota, Laura; Cimino, Luca; Zola, Enrica; Bonaguri, Chiara. - In: RHEUMATOLOGY INTERNATIONAL. - ISSN 0172-8172. - 21:4(2002), pp. 127-132. [10.1007/s00296-001-0158-7]
Autoimmune uveitis in children: clinical correlation between antinuclear antibody positivity and ocular recurrences.
MANZOTTI, Francesca;ORSONI, Gabriella;ZAVOTA, LAURA;CIMINO, Luca;ZOLA, Enrica;BONAGURI, Chiara
2002-01-01
Abstract
OBJECTIVE: The aim of this study was to identify the correlation between antinuclear antibody (ANA) titre and the onset and clinical course of uveitis in children with juvenile idiopathic arthritis (JIA) or without any other systemic autoimmune disease, i.e., idiopathic uveitis (IU). METHODS: Twenty-two patients affected by uveitis were examined. Ten had JIA-associated uveitis, 12 had IU. Follow-up ranged from 7 to 101 months. The ANA were titrated three times per year and additionally in case of ocular recurrences. All patients were treated with immunosuppressive drug combination therapy (IDCT). RESULTS: JIA-associated uveitis: ocular recurrences were noted in three ANA-positive patients and in one ANA-negative patient. IU uveitis: ocular recurrences were noted in one ANA-positive and in one ANA-negative patient. No significant rise in ANA titre was noted in either group during uveitis recurrence.File | Dimensione | Formato | |
---|---|---|---|
orsoni 2002.pdf
non disponibili
Tipologia:
Documento in Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
122.41 kB
Formato
Adobe PDF
|
122.41 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.