An unusual case of multiple myeloma with extramedullary dissemination and co-existing systemic non-necrotic granulomas is described. Immunoperoxidase staining revealed that both lymph node and bone marrow infiltrating plasma cells contained the same IgG-lambda type paraprotein, and that the granuloma epithelioid histiocytes contained intracytoplasmic lysozyme. As there was no evidence of either systemic infection or sarcoidosis, the non-necrotic granulomas may represent the host's response to the myeloma, not unlike the reaction observed in Hodgkin's disease or solid tumours. A causal association cannot, however, be entirely excluded.

Multiple myeloma with a sarcoidosis-like reaction / B. Falini; A. Tabilio; A. Velardi; C. Cernetti; F. Aversa; MF. Martelli. - In: SCANDINAVIAN JOURNAL OF HAEMATOLOGY. - ISSN 0036-553X. - 29(1982), pp. 211-216.

Multiple myeloma with a sarcoidosis-like reaction

AVERSA, Franco;
1982

Abstract

An unusual case of multiple myeloma with extramedullary dissemination and co-existing systemic non-necrotic granulomas is described. Immunoperoxidase staining revealed that both lymph node and bone marrow infiltrating plasma cells contained the same IgG-lambda type paraprotein, and that the granuloma epithelioid histiocytes contained intracytoplasmic lysozyme. As there was no evidence of either systemic infection or sarcoidosis, the non-necrotic granulomas may represent the host's response to the myeloma, not unlike the reaction observed in Hodgkin's disease or solid tumours. A causal association cannot, however, be entirely excluded.
Multiple myeloma with a sarcoidosis-like reaction / B. Falini; A. Tabilio; A. Velardi; C. Cernetti; F. Aversa; MF. Martelli. - In: SCANDINAVIAN JOURNAL OF HAEMATOLOGY. - ISSN 0036-553X. - 29(1982), pp. 211-216.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2439125
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