We report a case of haploidentical T-depleted BMT that engrafted durably after a highly immunosuppressive conditioning regimen. DNA polymorphism analysis showed that granulocytes and monocytes were donor type but T and B lymphocytes were host derived. Host tolerance to donor antigens was documented. The patient suffered from serious recurrent CMV infections until split chimaerism shifted to full donor type 2 years post-BMT. Seven years after BMT the patient remains in complete remission.
Unusual split chimaerism after mismatched T-depleted BMT / A., Terenzi; Aversa, Franco; A., Mencarelli; P., Pelicci; A., Velardi; K., Perruccio; Martelli, M. F.. - In: BONE MARROW TRANSPLANTATION. - ISSN 0268-3369. - 18:(1996), pp. 465-467.
Unusual split chimaerism after mismatched T-depleted BMT.
AVERSA, Franco;
1996-01-01
Abstract
We report a case of haploidentical T-depleted BMT that engrafted durably after a highly immunosuppressive conditioning regimen. DNA polymorphism analysis showed that granulocytes and monocytes were donor type but T and B lymphocytes were host derived. Host tolerance to donor antigens was documented. The patient suffered from serious recurrent CMV infections until split chimaerism shifted to full donor type 2 years post-BMT. Seven years after BMT the patient remains in complete remission.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
