We report a case of haploidentical T-depleted BMT that engrafted durably after a highly immunosuppressive conditioning regimen. DNA polymorphism analysis showed that granulocytes and monocytes were donor type but T and B lymphocytes were host derived. Host tolerance to donor antigens was documented. The patient suffered from serious recurrent CMV infections until split chimaerism shifted to full donor type 2 years post-BMT. Seven years after BMT the patient remains in complete remission.
Unusual split chimaerism after mismatched T-depleted BMT / A. Terenzi; F. Aversa; A. Mencarelli; P. Pelicci; A. Velardi; K. Perruccio; MF. Martelli. - In: BONE MARROW TRANSPLANTATION. - ISSN 0268-3369. - 18(1996), pp. 465-467.
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