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EnglishAlthough adoptive transfer of donor lymphocytes protects from infections and relapse after allogeneic hematopoietic stem cell transplantation in both mice and in men, it is associated with a high risk of graft versus host disease (GvHD) which rises with HLA mismatching and the number of T lymphocytes that are infused. Elimination/reduction of alloreactive donor T lymphocytes is an appealing approach and several strategies have been proposed. Here we describe generation of anti-3rd party T lymphocytes under conditions of IL-2 deprivation and their effects in a pre-clinical murine model. Our results clearly indicated that anti-3rd party T lymphocytes generated on a large scale by means of IL-2 deprivation maintain a broad T cell repertoire, do not proliferate in a mixed lymphocyte reaction and do not cause GvHD in NOD-SCID mice. These anti-3rd party lymphocytes contain a large adaptive T regulatory cell subset which might contribute to in vitro and in vivo immune modulation.
Large-scale generation of human allodepleted anti-3rd party lymphocytes / M. De Ioanni; M. Di Ianni; E. Bonifacio;L. Moretti ; D. Cecchini; F. Bazzucchi; A. Terenzi; T. Aloisi; F. Falzetti; F. Aversa; Y. Reisner; MF. Martelli; A. Tabilio. - In: BLOOD CELLS, MOLECULES, & DISEASES. - ISSN 1079-9796. - 40(2008), pp. 106-112.
| Tipologia ministeriale: | Articolo su rivista | |
| Appare nelle tipologie: | 1.1 Articolo su rivista |
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| File | Descrizione | Tipologia | Licenza | |
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| Blood Cell Mol Disease 2008.pdf | Documento in Post-print | NON PUBBLICO - Accesso privato/ristretto | Administrator Richiedi una copia |
http://hdl.handle.net/11381/2438674
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