Continuous surveillance of invasive fungal infection: a realistic goal for the near future.

Using the Prospective Antifungal Therapy (PATH) Alliance registry, Neofytos et al. [1] investigated the epidemiology and outcome of invasive fungal infections (IFIs) in hematopoietic stem cell transplant (HSCT) recipients. Because use of Web-based registries is pivotal for progress in understanding IFIs, the Italian Hema e-Chart Group is also engaged in a prospective, multicenter, observational study designed to analyze all febrile events in patients with hematological malignancies (L.P., M.C., and A.N., unpublished data). Hema e-chart prospectively collects high-quality data derived from clinical experience and provides information on epidemiology and prophylactic and/or therapeutic drug use for IFIs. Distribution of investigating centers across Italy and a potentially large patient cohort facilitate the study of IFIs and the identification of appropriate subgroups for diverse research interests