Hastening posttransplantation immune reconstitution is a key challenge in human leukocyte antigen (HLA)-haploidentical hematopoietic stem-cell transplantation (HSCT). In experimental models of mismatched HSCT, T-regulatory cells (Tregs) when co-infused with conventional T cells (Tcons) favored posttransplantation immune reconstitution and prevented lethal graft-versus-host disease (GVHD). In the present study, we evaluated the impact of early infusion of Tregs, followed by Tcons, on GVHD prevention and immunologic reconstitution in 28 patients with high-risk hematologic malignancies who underwent HLA-haploidentical HSCT. We show for the first time in humans that adoptive transfer of Tregs prevented GVHD in the absence of any posttransplantation immunosuppression, promoted lymphoid reconstitution, improved immunity to opportunistic pathogens, and did not weaken the graft-versus-leukemia effect. This study provides evidence that Tregs are a conserved mechanism in humans.

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation / M., Di Ianni; F., Falzetti; A., Carotti; A., Terenzi; F., Castellino; E., Bonifacio; B., Del Papa; T., Zei; Ostini, R. I.; D., Cecchini; T., Aloisi; K., Perruccio; L., Ruggeri; C., Balucani; A., Pierini; P., Sportoletti; C., Aristei; B., Falini; Y., Reisner; A., Velardi; Aversa, Franco; Martelli, M. F.. - In: BLOOD. - ISSN 0006-4971. - 117:14(2011), pp. 3921-3928.

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

AVERSA, Franco;
2011-01-01

Abstract

Hastening posttransplantation immune reconstitution is a key challenge in human leukocyte antigen (HLA)-haploidentical hematopoietic stem-cell transplantation (HSCT). In experimental models of mismatched HSCT, T-regulatory cells (Tregs) when co-infused with conventional T cells (Tcons) favored posttransplantation immune reconstitution and prevented lethal graft-versus-host disease (GVHD). In the present study, we evaluated the impact of early infusion of Tregs, followed by Tcons, on GVHD prevention and immunologic reconstitution in 28 patients with high-risk hematologic malignancies who underwent HLA-haploidentical HSCT. We show for the first time in humans that adoptive transfer of Tregs prevented GVHD in the absence of any posttransplantation immunosuppression, promoted lymphoid reconstitution, improved immunity to opportunistic pathogens, and did not weaken the graft-versus-leukemia effect. This study provides evidence that Tregs are a conserved mechanism in humans.
2011
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation / M., Di Ianni; F., Falzetti; A., Carotti; A., Terenzi; F., Castellino; E., Bonifacio; B., Del Papa; T., Zei; Ostini, R. I.; D., Cecchini; T., Aloisi; K., Perruccio; L., Ruggeri; C., Balucani; A., Pierini; P., Sportoletti; C., Aristei; B., Falini; Y., Reisner; A., Velardi; Aversa, Franco; Martelli, M. F.. - In: BLOOD. - ISSN 0006-4971. - 117:14(2011), pp. 3921-3928.
File in questo prodotto:
File Dimensione Formato  
Di Ianni, Blood-2011.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 1.82 MB
Formato Adobe PDF
1.82 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2438576
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 863
  • ???jsp.display-item.citation.isi??? 350
social impact