Much progress has been made in the clinical, biological and technical aspects of the T-cell-depleted haploidentical hematopoietic stem cell transplantation (HSCT). Our experience demonstrates that infusing a megadose of extensively T-cell-depleted hematopoietic peripheral blood stem cells after an immuno-myeloablative conditioning regimen in acute leukemia patients ensures sustained engraftment with minimal GvHD without the need of any post-transplant immunosuppressive treatment. Since our first successful pilot study, our efforts have concentrated on developing new conditioning regimens, optimizing the graft processing and improving the post-transplant immunological recovery. The results we have so far achieved in high risk acute leukemia patients show that haploidentical transplantation is now a clinical reality. The present challenge is to reduce post-transplant infectious mortality and several strategies are being tested.

Setting the standard in T-cell-depleted haploidentical transplantation and beyond / Aversa, Franco. - In: BAILLIERE'S BEST PRACTICE IN CLINICAL HAEMATOLOGY. - ISSN 1521-6926. - 24:3(2011), pp. 325-329.

Setting the standard in T-cell-depleted haploidentical transplantation and beyond

AVERSA, Franco
2011-01-01

Abstract

Much progress has been made in the clinical, biological and technical aspects of the T-cell-depleted haploidentical hematopoietic stem cell transplantation (HSCT). Our experience demonstrates that infusing a megadose of extensively T-cell-depleted hematopoietic peripheral blood stem cells after an immuno-myeloablative conditioning regimen in acute leukemia patients ensures sustained engraftment with minimal GvHD without the need of any post-transplant immunosuppressive treatment. Since our first successful pilot study, our efforts have concentrated on developing new conditioning regimens, optimizing the graft processing and improving the post-transplant immunological recovery. The results we have so far achieved in high risk acute leukemia patients show that haploidentical transplantation is now a clinical reality. The present challenge is to reduce post-transplant infectious mortality and several strategies are being tested.
2011
Setting the standard in T-cell-depleted haploidentical transplantation and beyond / Aversa, Franco. - In: BAILLIERE'S BEST PRACTICE IN CLINICAL HAEMATOLOGY. - ISSN 1521-6926. - 24:3(2011), pp. 325-329.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2438556
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