Allogeneic transplantation is a potentially curative strategy for patients who have an advanced or high risk hematological malignancy. Patient who have siblings have only 25-30% suitable HLA-matched related donor. For those patients who lack a HLA-matched related donor, most transplant center would immediately start the search for an 8/8 allele level HLA-matched unrelated donor. While the chances of finding a 8/8 allele level HLA-matched unrelated donor for caucasian patients is about 60-70%, the chances of finding a matched unrelated donor for patients belonging to ethnical minorities ranges from 10-25%. Thus, transplant centers around the world have been investigating the use of alternative donors in order to close the gap in donor availability.
Back to the future: mismatched unrelated donor, haploidentical related donor, or unrelated umbilical cord blood transplantation? / C., Anasetti; Aversa, Franco; Brunstein, C. G.. - In: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. - ISSN 1083-8791. - 18:(2012), pp. S161-S165.
Back to the future: mismatched unrelated donor, haploidentical related donor, or unrelated umbilical cord blood transplantation?
AVERSA, Franco;
2012-01-01
Abstract
Allogeneic transplantation is a potentially curative strategy for patients who have an advanced or high risk hematological malignancy. Patient who have siblings have only 25-30% suitable HLA-matched related donor. For those patients who lack a HLA-matched related donor, most transplant center would immediately start the search for an 8/8 allele level HLA-matched unrelated donor. While the chances of finding a 8/8 allele level HLA-matched unrelated donor for caucasian patients is about 60-70%, the chances of finding a matched unrelated donor for patients belonging to ethnical minorities ranges from 10-25%. Thus, transplant centers around the world have been investigating the use of alternative donors in order to close the gap in donor availability.File | Dimensione | Formato | |
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