AIMS: Bone marrow mesenchymal stromal cell (BMStC) transplantation into the infarcted heart improves left ventricular function and cardiac remodelling. However, it has been suggested that tissue-specific cells may be better for cardiac repair than cells from other sources. The objective of the present work has been the comparison of in vitro and in vivo properties of adult human cardiac stromal cells (CStC) to those of syngeneic BMStC. METHODS AND RESULTS: Although CStC and BMStC exhibited a similar immunophenotype, their gene, microRNA, and protein expression profiles were remarkably different. Biologically, CStC, compared with BMStC, were less competent in acquiring the adipogenic and osteogenic phenotype but more efficiently expressed cardiovascular markers. When injected into the heart, in rat a model of chronic myocardial infarction, CStC persisted longer within the tissue, migrated into the scar, and differentiated into adult cardiomyocytes better than BMStC. CONCLUSION: Our findings demonstrate that although CStC and BMStC share a common stromal phenotype, CStC present cardiovascular-associated features and may represent an important cell source for more efficient cardiac repair

Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin / Rossini A, A.; Frati, Caterina; Lagrasta, Costanza Anna Maria; Graiani, Gallia; Scopece, A.; Cavalli, S.; Musso, E.; Baccarin, M.; Di Segni, M.; Fagnoni, F.; Germani, A.; Quaini, E.; Mayr, M.; Xu, Q.; Barbuti, A.; Difrancesco, D.; Pompilio, G.; Quaini, Federico; Gaetano, C.; Capogrossi, M. C.. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - 89:(2011), pp. 650-660.

Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin.

FRATI, Caterina;LAGRASTA, Costanza Anna Maria;GRAIANI, Gallia;E. Musso;QUAINI, Federico;
2011-01-01

Abstract

AIMS: Bone marrow mesenchymal stromal cell (BMStC) transplantation into the infarcted heart improves left ventricular function and cardiac remodelling. However, it has been suggested that tissue-specific cells may be better for cardiac repair than cells from other sources. The objective of the present work has been the comparison of in vitro and in vivo properties of adult human cardiac stromal cells (CStC) to those of syngeneic BMStC. METHODS AND RESULTS: Although CStC and BMStC exhibited a similar immunophenotype, their gene, microRNA, and protein expression profiles were remarkably different. Biologically, CStC, compared with BMStC, were less competent in acquiring the adipogenic and osteogenic phenotype but more efficiently expressed cardiovascular markers. When injected into the heart, in rat a model of chronic myocardial infarction, CStC persisted longer within the tissue, migrated into the scar, and differentiated into adult cardiomyocytes better than BMStC. CONCLUSION: Our findings demonstrate that although CStC and BMStC share a common stromal phenotype, CStC present cardiovascular-associated features and may represent an important cell source for more efficient cardiac repair
2011
Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin / Rossini A, A.; Frati, Caterina; Lagrasta, Costanza Anna Maria; Graiani, Gallia; Scopece, A.; Cavalli, S.; Musso, E.; Baccarin, M.; Di Segni, M.; Fagnoni, F.; Germani, A.; Quaini, E.; Mayr, M.; Xu, Q.; Barbuti, A.; Difrancesco, D.; Pompilio, G.; Quaini, Federico; Gaetano, C.; Capogrossi, M. C.. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - 89:(2011), pp. 650-660.
File in questo prodotto:
File Dimensione Formato  
H vs BMsc.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: Creative commons
Dimensione 597.32 kB
Formato Adobe PDF
597.32 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2329506
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 106
  • ???jsp.display-item.citation.isi??? 99
social impact