The chloromethylation of calix[4]arene 1a and of the methyl ethers of calix[6]arene 1b and calix[8]arene 1c, using chloromethyl n-octyl ether and SnCl4 in chloroform at room temperature has been performed in good yield for the first time. The chloromethylated products 2a-c have been used as intermediates to introduce on calixarenes phosphonic acid groups which render these macrocycles water soluble and potentially useful in Host Guest Chemistry.
Chloromethylation of Calix[4]arenes and Synthesis of New Water Soluble Macrocyclic Hosts / M., Almi; Arduini, Arturo; Casnati, Alessandro; Pochini, Andrea; Ungaro, Rocco. - In: TETRAHEDRON. - ISSN 0040-4020. - 45:(1989), pp. 2177-2182. [10.1016/S0040-4020(01)80077-6]
Chloromethylation of Calix[4]arenes and Synthesis of New Water Soluble Macrocyclic Hosts
ARDUINI, Arturo;CASNATI, Alessandro;POCHINI, Andrea;UNGARO, Rocco
1989-01-01
Abstract
The chloromethylation of calix[4]arene 1a and of the methyl ethers of calix[6]arene 1b and calix[8]arene 1c, using chloromethyl n-octyl ether and SnCl4 in chloroform at room temperature has been performed in good yield for the first time. The chloromethylated products 2a-c have been used as intermediates to introduce on calixarenes phosphonic acid groups which render these macrocycles water soluble and potentially useful in Host Guest Chemistry.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
