The possibilty that dehydroepiandrosterone is metabolised in hiuman plasma was studied by column and thin-layer chromatography. The results obtained indicated that a time depenmdentr dispappearance of DHEA is matched by the appearance of newly formed species that may represent DHEA conversion by-products. Neither disappearance of DHEA nor formation of the alleged conversion by-products was observed when reactions were performed under conditions in which plasma enzymes were removed or inactivated. These results suggest that, in plasma, DHEA is partially transformed into different substances, and that the conversion reactions are catalyzed by enzymes present in this tissue.
Dehydroepiandrosterone metabolism in human plasma / Albo, F; Barbaccia, M. L.; Cavazza, Antonella; Marini, M; Roda, L. G.. - In: HORMONE AND METABOLIC RESEARCH. - ISSN 0018-5043. - 35:(2003), pp. 104-108. [10.1055/s-2003-39052]
Dehydroepiandrosterone metabolism in human plasma
CAVAZZA, Antonella;
2003-01-01
Abstract
The possibilty that dehydroepiandrosterone is metabolised in hiuman plasma was studied by column and thin-layer chromatography. The results obtained indicated that a time depenmdentr dispappearance of DHEA is matched by the appearance of newly formed species that may represent DHEA conversion by-products. Neither disappearance of DHEA nor formation of the alleged conversion by-products was observed when reactions were performed under conditions in which plasma enzymes were removed or inactivated. These results suggest that, in plasma, DHEA is partially transformed into different substances, and that the conversion reactions are catalyzed by enzymes present in this tissue.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
