A continuous-flow two-step process for the production of multifunctional intermediate compounds was performed with a combination of two column reactors packed with different organic immobilized catalysts. The first step of the reaction, nitroaldol condensation between aromatic aldehydes and nitromethane, is promoted by a silica gel-supported primary amine; the second step, Michael addition of β-dicarbonyl compounds to the nitrostyrenes obtained in the first step, is catalyzed by a silica gel-supported guanidine TBD. In both cases, the catalysts can be directly reused for several runs with no significant changes in activity.
Use of Immobilized Organic Base Catalysts for Continuous-Flow Fine Chemical Synthesis / Soldi, Laura; Ferstl, W; Loebbecke, S; Maggi, Raimondo; Malmassari, C; Sartori, Giovanni; Yada, S.. - In: JOURNAL OF CATALYSIS. - ISSN 0021-9517. - 258:(2008), pp. 289-295. [10.1016/j.jcat.2008.07.005]
Use of Immobilized Organic Base Catalysts for Continuous-Flow Fine Chemical Synthesis
SOLDI, Laura;MAGGI, Raimondo;SARTORI, Giovanni;
2008-01-01
Abstract
A continuous-flow two-step process for the production of multifunctional intermediate compounds was performed with a combination of two column reactors packed with different organic immobilized catalysts. The first step of the reaction, nitroaldol condensation between aromatic aldehydes and nitromethane, is promoted by a silica gel-supported primary amine; the second step, Michael addition of β-dicarbonyl compounds to the nitrostyrenes obtained in the first step, is catalyzed by a silica gel-supported guanidine TBD. In both cases, the catalysts can be directly reused for several runs with no significant changes in activity.File | Dimensione | Formato | |
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