Inhibition of angiogenesis is an important new approach for cancer treatment and the research on this topic deserve special attention. 2-Methoxyestradiol (2-ME), a molecule shown to possess antiangiogenic activity, is a naturally occurring derivative of estradiol which can be potentially produced in the ovarian follicle. This study was therefore aimed firstly to asses 2-ME content in swine follicular fluid. Moreover, we evaluated the effect of this substance on VEGF production, superoxide anion generation (O(2)(-)) and superoxide dismuatase activity in granulosa cells. Our data evidence that 2-ME is present in follicular fluid where it potentially acts as a physiological inhibitor of angiogenesis by reducing VEGF production by granulosa cells: this effect could be mediated by a decrease of O(2)(-) generation
Antiangiogenesis in swine ovarian follicle: a potential role for 2-methoxyestradiol / Basini, Giuseppina; Bussolati, Simona; S. E., Santini; Bianchi, Federica; Careri, Maria; Mangia, Alessandro; Musci, Marilena; Grasselli, Francesca. - In: STEROIDS. - ISSN 0039-128X. - 72:(2007), pp. 660-665. [10.1016/j.steroids.2007.05.002]
Antiangiogenesis in swine ovarian follicle: a potential role for 2-methoxyestradiol
BASINI, Giuseppina
;BUSSOLATI, Simona;BIANCHI, Federica;CARERI, Maria;MANGIA, Alessandro;MUSCI, Marilena;GRASSELLI, Francesca
2007-01-01
Abstract
Inhibition of angiogenesis is an important new approach for cancer treatment and the research on this topic deserve special attention. 2-Methoxyestradiol (2-ME), a molecule shown to possess antiangiogenic activity, is a naturally occurring derivative of estradiol which can be potentially produced in the ovarian follicle. This study was therefore aimed firstly to asses 2-ME content in swine follicular fluid. Moreover, we evaluated the effect of this substance on VEGF production, superoxide anion generation (O(2)(-)) and superoxide dismuatase activity in granulosa cells. Our data evidence that 2-ME is present in follicular fluid where it potentially acts as a physiological inhibitor of angiogenesis by reducing VEGF production by granulosa cells: this effect could be mediated by a decrease of O(2)(-) generationI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
