The direct expression and production of the critical osteoclastogenic factor, the receptor activator of NF-kB ligand (RANKL), is a matter of controversy. In this study we definitively demonstrate by both qualitative and quantitative polymerase chain reaction analysis that human myeloma cells do not express significant levels of RANKL mRNA or produce RANKL able to stimulate osteoclast formation.
Lack of receptor activator of nuclear factor-kB ligand (RANKL) expression andfunctional production by human multiple myeloma cells / Giuliani, Nicola; Colla, S; Morandi, F; BARILLE NION, S; Rizzoli, Vittorio. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 90:(2005), pp. 275-278.
Lack of receptor activator of nuclear factor-kB ligand (RANKL) expression andfunctional production by human multiple myeloma cells
GIULIANI, Nicola;RIZZOLI, Vittorio
2005-01-01
Abstract
The direct expression and production of the critical osteoclastogenic factor, the receptor activator of NF-kB ligand (RANKL), is a matter of controversy. In this study we definitively demonstrate by both qualitative and quantitative polymerase chain reaction analysis that human myeloma cells do not express significant levels of RANKL mRNA or produce RANKL able to stimulate osteoclast formation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
