A high-affinity ligand of cholera toxin, the divalent glycocalix[4]arene 1, was obtained by exploiting a combination of structure-based design of glycomimetic monovalent ligands and affinity enhancements by multivalent presentation through a calix[4]arene scaffold. It exhibits a slightly higher affinity for the toxin than its natural ligand, the GM1 oligosaccharide.
A Synthetic Divalent Cholera Toxin Glycocalix[4]arene Ligand Having Higher Affinity Than Natural GM1 Oligosaccharide / D., Arosio; Fontanella, Marco; Baldini, Laura; L., Mauri; A., Bernardi; Casnati, Alessandro; Sansone, Francesco; Ungaro, Rocco. - In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - ISSN 0002-7863. - 127:(2005), pp. 3660-3661. [10.1021/ja0444029]
A Synthetic Divalent Cholera Toxin Glycocalix[4]arene Ligand Having Higher Affinity Than Natural GM1 Oligosaccharide
FONTANELLA, Marco;BALDINI, Laura;CASNATI, Alessandro;SANSONE, Francesco;UNGARO, Rocco
2005-01-01
Abstract
A high-affinity ligand of cholera toxin, the divalent glycocalix[4]arene 1, was obtained by exploiting a combination of structure-based design of glycomimetic monovalent ligands and affinity enhancements by multivalent presentation through a calix[4]arene scaffold. It exhibits a slightly higher affinity for the toxin than its natural ligand, the GM1 oligosaccharide.| File | Dimensione | Formato | |
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