In this study, we describe an extremely rare case of coexistence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.
Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia / Colla, S; Sammarelli, Gabriella; Crugnola, M; Ascani, S; Sabbatini, E; Bonomini, S; Hojden, M; Craviotto, Luisa; DE CELIS, I; Morandi, F; Caramatti, Cecilia; Rizzoli, Vittorio; Giuliani, Nicola. - In: EUROPEAN JOURNAL OF HAEMATOLOGY. - ISSN 0902-4441. - 72:(2004), pp. 361-365. [10.1111/j.1600-0609.2004.00222.x]
Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia
SAMMARELLI, Gabriella;CRAVIOTTO, Luisa;CARAMATTI, Cecilia;RIZZOLI, Vittorio;GIULIANI, Nicola
2004-01-01
Abstract
In this study, we describe an extremely rare case of coexistence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.| File | Dimensione | Formato | |
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