GILEA, ALEXANDRU IONUT
GILEA, ALEXANDRU IONUT
Dipartimento di Scienze Chimiche, della Vita e della Sostenibilità Ambientale
A simple organism to address big questions: how Saccharomyces cerevisiae can support mitochondrial medicine
2024-01-01 Magistrati, M.; Giandebiaggi, N.; Gilea, A. I.; Baruffini, E.; Dallabona, C.
A yeast-based repurposing approach revealed modulation of dNTP pool as a therapeutic target to treat mitochondrial DNA depletion syndromes
2021-01-01 DI PUNZIO, Giulia; Gilberti, Micol; Magistrati, Martina; Leotta, Antonella; Gilea, ALEXANDRU IONUT; Baruffini, Enrico; Lodi, Tiziana; Donnini, Claudia; Dallabona, Cristina
Drug Drop Test: How to Quickly Identify Potential Therapeutic Compounds for Mitochondrial Diseases Using Yeast Saccharomyces cerevisiae
2023-01-01 Magistrati, Martina; Gilea, Alexandru Ionut; Gerra, Maria Carla; Baruffini, Enrico; Dallabona, Cristina
Exploring Yeast as a Study Model of Pantothenate Kinase-Associated Neurodegeneration and for the Identification of Therapeutic Compounds
2020-01-01 CECCATELLI BERTI, Camilla; Gilea, ALEXANDRU IONUT; Armando De Gregorio, Marco; Goffrini, Paola
Functional characterization of archaic-specific variants in mitonuclear genes: insights from comparative analysis in S. cerevisiae
2024-01-01 Aneli, S; Ceccatelli Berti, C; Gilea, Ai; Birolo, G; Mutti, G; Pavesi, A; Baruffini, E; Goffrini, P; Capelli, C
Identification of drugs for the treatment of POLG-related diseases by means of a high throughput drug repurposing approach performed in Saccharomyces cerevisiae
2023-01-01 Baruffini, Enrico; Lodi, Tiziana; Brañas Casas, Raquel; Risato, Giovanni; Argenton, Francesco; Tiso, Natascia; Gilea, ALEXANDRU IONUT
Identification of drugs for the treatment of POLG-related diseases by means of a high throughput drug repurposing approach performed in Saccharomyces cerevisiae
2021-01-01 Gilea, ALEXANDRU IONUT; Branas Casas, Raquel; Argenton, Francesco; Tiso, Natascia; Lodi, Tiziana; Baruffini, Enrico
Modopathies Caused by Mutations in Genes Encoding for Mitochondrial RNA Modifying Enzymes: Molecular Mechanisms and Yeast Disease Models
2023-01-01 Magistrati, Martina; Gilea, ALEXANDRU IONUT; CECCATELLI BERTI, Camilla; Baruffini, Enrico; Dallabona, Cristina
Saccharomyces cerevisiae as a tool for studying mutations in nuclear genes involved in diseases caused by mitochondrial DNA instability
2021-01-01 Gilea, A. I.; Ceccatelli Berti, C.; Magistrati, M.; Di Punzio, G.; Goffrini, P.; Baruffini, E.; Dallabona, C.
Severe mitochondrial encephalomyopathy caused by de novo variants in OPA1 gene
2024-01-01 Di Nottia, M.; Rizza, T.; Baruffini, E.; Nesti, C.; Torraco, A.; Diodato, D.; Martinelli, D.; Dal Canto, F.; Gilea, A. I.; Zoccola, M.; Siri, B.; Dionisi-Vici, C.; Bertini, E.; Santorelli, F. M.; Goffrini, P.; Carrozzo, R.
The absence of SNF8 in the yeast Saccharomyces cerevisiae leads to mitochondrial dysfunction
2024-01-01 Gilea, ALEXANDRU IONUT; Magnoni, Penelope; Fiorini, Claudio; Moresco, Monica; Degiorgi, Andrea; Brugger, Melanie; Wagner, Matias; Carelli, Valerio; Maresca, Alessandra; Baruffini, Enrico; Caporali, Leonardo
The Saccharomyces cerevisiae mitochondrial DNA polymerase and its contribution to the knowledge about human POLG-related disorders
2023-01-01 Gilea, Alexandru Ionut; Magistrati, Martina; Notaroberto, Ilenia; Tiso, Natascia; Dallabona, Cristina; Baruffini, Enrico
The yeast Saccharomyces cerevisiae as a model to deepen the knowledge about the mitochondrial metallopeptidase PITRM1 in health and disease
2024-01-01 Magistrati, M.; Gilea, A. I.; Baruffini, E.; Dallabona, C.
Transcriptomics on yeast models to deepen the knowledge of mitochondrial disease-associated pathways
2024-01-01 Izzo, R.; Magistrati, M.; Foderà, G. A.; Gilea, A. I.; Giandebiaggi, N.; Barresi, M.; Brunetti, D.; Dallabona, C.; Legati, A.; Ghezzi, D.
Yeast as a model for searching drugs against pathologies caused by mutations in ACO2
2023-01-01 Gilea, ALEXANDRU IONUT; Figuccia, Sonia; CECCATELLI BERTI, Camilla; Fiorini, Claudio; Carelli, Valerio; Caporali, Leonardo; Baruffini, Enrico
Yeast-Based Functional Investigation of ELAC2 Variants in Mitochondrial Dysfunction
2024-01-01 CECCATELLI BERTI, Camilla; Gilea, ALEXANDRU IONUT; di Nottia, Michela; Castiglioni, Claudia; Zoccola, Martina; Goffrini, Paola; Bertini, Enrico; Baruffini, Enrico; Carrozzo, Rosalba
Zebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment
2024-01-01 Branas Casas, R.; Zuppardo, A.; Risato, G.; Dinarello, A.; Celeghin, R.; Fontana, C.; Grelloni, E.; Gilea, A. I.; Viscomi, C.; Rasola, A.; Dalla Valle, L.; Lodi, T.; Baruffini, E.; Facchinello, N.; Argenton, F.; Tiso, N.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A simple organism to address big questions: how Saccharomyces cerevisiae can support mitochondrial medicine | 1-gen-2024 | Magistrati, M.; Giandebiaggi, N.; Gilea, A. I.; Baruffini, E.; Dallabona, C. | |
| A yeast-based repurposing approach revealed modulation of dNTP pool as a therapeutic target to treat mitochondrial DNA depletion syndromes | 1-gen-2021 | DI PUNZIO, Giulia; Gilberti, Micol; Magistrati, Martina; Leotta, Antonella; Gilea, ALEXANDRU IONUT; Baruffini, Enrico; Lodi, Tiziana; Donnini, Claudia; Dallabona, Cristina | |
| Drug Drop Test: How to Quickly Identify Potential Therapeutic Compounds for Mitochondrial Diseases Using Yeast Saccharomyces cerevisiae | 1-gen-2023 | Magistrati, Martina; Gilea, Alexandru Ionut; Gerra, Maria Carla; Baruffini, Enrico; Dallabona, Cristina | |
| Exploring Yeast as a Study Model of Pantothenate Kinase-Associated Neurodegeneration and for the Identification of Therapeutic Compounds | 1-gen-2020 | CECCATELLI BERTI, Camilla; Gilea, ALEXANDRU IONUT; Armando De Gregorio, Marco; Goffrini, Paola | |
| Functional characterization of archaic-specific variants in mitonuclear genes: insights from comparative analysis in S. cerevisiae | 1-gen-2024 | Aneli, S; Ceccatelli Berti, C; Gilea, Ai; Birolo, G; Mutti, G; Pavesi, A; Baruffini, E; Goffrini, P; Capelli, C | |
| Identification of drugs for the treatment of POLG-related diseases by means of a high throughput drug repurposing approach performed in Saccharomyces cerevisiae | 1-gen-2023 | Baruffini, Enrico; Lodi, Tiziana; Brañas Casas, Raquel; Risato, Giovanni; Argenton, Francesco; Tiso, Natascia; Gilea, ALEXANDRU IONUT | |
| Identification of drugs for the treatment of POLG-related diseases by means of a high throughput drug repurposing approach performed in Saccharomyces cerevisiae | 1-gen-2021 | Gilea, ALEXANDRU IONUT; Branas Casas, Raquel; Argenton, Francesco; Tiso, Natascia; Lodi, Tiziana; Baruffini, Enrico | |
| Modopathies Caused by Mutations in Genes Encoding for Mitochondrial RNA Modifying Enzymes: Molecular Mechanisms and Yeast Disease Models | 1-gen-2023 | Magistrati, Martina; Gilea, ALEXANDRU IONUT; CECCATELLI BERTI, Camilla; Baruffini, Enrico; Dallabona, Cristina | |
| Saccharomyces cerevisiae as a tool for studying mutations in nuclear genes involved in diseases caused by mitochondrial DNA instability | 1-gen-2021 | Gilea, A. I.; Ceccatelli Berti, C.; Magistrati, M.; Di Punzio, G.; Goffrini, P.; Baruffini, E.; Dallabona, C. | |
| Severe mitochondrial encephalomyopathy caused by de novo variants in OPA1 gene | 1-gen-2024 | Di Nottia, M.; Rizza, T.; Baruffini, E.; Nesti, C.; Torraco, A.; Diodato, D.; Martinelli, D.; Dal Canto, F.; Gilea, A. I.; Zoccola, M.; Siri, B.; Dionisi-Vici, C.; Bertini, E.; Santorelli, F. M.; Goffrini, P.; Carrozzo, R. | |
| The absence of SNF8 in the yeast Saccharomyces cerevisiae leads to mitochondrial dysfunction | 1-gen-2024 | Gilea, ALEXANDRU IONUT; Magnoni, Penelope; Fiorini, Claudio; Moresco, Monica; Degiorgi, Andrea; Brugger, Melanie; Wagner, Matias; Carelli, Valerio; Maresca, Alessandra; Baruffini, Enrico; Caporali, Leonardo | |
| The Saccharomyces cerevisiae mitochondrial DNA polymerase and its contribution to the knowledge about human POLG-related disorders | 1-gen-2023 | Gilea, Alexandru Ionut; Magistrati, Martina; Notaroberto, Ilenia; Tiso, Natascia; Dallabona, Cristina; Baruffini, Enrico | |
| The yeast Saccharomyces cerevisiae as a model to deepen the knowledge about the mitochondrial metallopeptidase PITRM1 in health and disease | 1-gen-2024 | Magistrati, M.; Gilea, A. I.; Baruffini, E.; Dallabona, C. | |
| Transcriptomics on yeast models to deepen the knowledge of mitochondrial disease-associated pathways | 1-gen-2024 | Izzo, R.; Magistrati, M.; Foderà, G. A.; Gilea, A. I.; Giandebiaggi, N.; Barresi, M.; Brunetti, D.; Dallabona, C.; Legati, A.; Ghezzi, D. | |
| Yeast as a model for searching drugs against pathologies caused by mutations in ACO2 | 1-gen-2023 | Gilea, ALEXANDRU IONUT; Figuccia, Sonia; CECCATELLI BERTI, Camilla; Fiorini, Claudio; Carelli, Valerio; Caporali, Leonardo; Baruffini, Enrico | |
| Yeast-Based Functional Investigation of ELAC2 Variants in Mitochondrial Dysfunction | 1-gen-2024 | CECCATELLI BERTI, Camilla; Gilea, ALEXANDRU IONUT; di Nottia, Michela; Castiglioni, Claudia; Zoccola, Martina; Goffrini, Paola; Bertini, Enrico; Baruffini, Enrico; Carrozzo, Rosalba | |
| Zebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment | 1-gen-2024 | Branas Casas, R.; Zuppardo, A.; Risato, G.; Dinarello, A.; Celeghin, R.; Fontana, C.; Grelloni, E.; Gilea, A. I.; Viscomi, C.; Rasola, A.; Dalla Valle, L.; Lodi, T.; Baruffini, E.; Facchinello, N.; Argenton, F.; Tiso, N. |