DEVELOPMENT OF BIOMATERIALS FOR THE COMBINED LOCAL DELIVERY OF AMOXICILLIN AND METRONIDAZOLE IN ORAL REGENERATIVE APPLICATIONS

INTRODUCTION: Regenerative biomaterials for bone healing and surgical site infection prevention. Local antibiotic delivery enables targeted antimicrobial therapy with reduced systemic exposure. MgHA biomaterials combine osteoconductivity and local drug delivery. The aim of the work is to evaluate the loading of an injectable MgHA paste with amoxicillin and metronidazole for simultaneous bone regeneration and local antimicrobial therapy. MATERIALS AND METHODS: A moldable MgHA paste was prepared as a ready‑to‑use injectable putty. Antibiotics loading was performed and drug release was assessed at 37°C. Quantification of released antibiotics was performed by HPLC-UV for up to 7 days. RESULTS: The release profile demonstrated Mg, Ca, and PO₄ concentrations within the clinically relevant range for bone regeneration, with magnesium identified as the predominant bioactive ion released from the scaffold’s ceramic matrix. CONCLUSION: MgHA biomaterials provide controlled local delivery of combined antibiotics while promoting oral tissue regeneration. This multifunctional approach shows strong potential for clinical translation.