Relazione introduttiva al Convegno "Il ruolo delle Corti costituzionali e la protezione delle generazioni future", 8-9 Novembre 2024, Università di Messina

Yeast-Based Functional Investigation of ELAC2 Variants in Mitochondrial Dysfunction

Background and goals: ELAC2 encodes the mitochondrial RNase Z, which is crucial for removing 3′ extensions from pre-tRNAs, a key step in tRNA biogenesis (Brzezniak et al, 2011; Rossmanith, 2011). Pathogenic ELAC2 variants affect mitochondrial gene expression, leading to respiratory chain deficiencies, hypertrophic cardiomyopathy (HCM), and lactic acidosis (Haack et al, 2013; Saoura et al, 2019). Compound heterozygous ELAC2 mutations were identified in a Chilean patient with epilepsy, ...

Knowledge collection in aircraft passenger seat assembly: Insight for a conceptual design method development

In the field of aircraft system engineering, this research work aims to bridge the gap between conceptual design and quantitative analysis, with a specific focus on the installation of aircraft passenger seats. To achieve this objective, a comprehensive analysis of seat installation process for commercial aircraft was carried out to identify and describe criticalities associated with this manufacturing phase. Different means were used to gather information, starting from the analysis of techn...

Design Function Matrix (DFM) to identify modules for product architectures at the conceptual design phase

The Design Function Matrix (DFM) offers a comprehensive approach to modular design in product development. It integrates a structured methodology for analyzing and identifying modular components during the early stages of design, highlighting the importance of modularity for efficiency and lifecycle cost reduction. The DFM framework focuses on functional analysis, particularly the interactions of Material, Energy, and Signal flows. By mapping these flow interactions within a matrix structure,...