Since Franz Schardinger first identified xanthine dehydrogenase (XDH) 123 years ago, the oxidation of purines to uric acid via the XDH pathway has been recognized as a central route in purine metabolism. Two recent studies now describe a previously unknown anaerobic uric acid degradation pathway in gut bacteria, highlighting its contribution to systemic urate homeostasis and its therapeutic promise for hyperuricemia and gout.
Urate metabolism in the gut / Percudani, R.. - In: LIFE METABOLISM. - ISSN 2755-0230. - 5:1(2026). [10.1093/lifemeta/loaf041]
Urate metabolism in the gut
Percudani R.
2026-01-01
Abstract
Since Franz Schardinger first identified xanthine dehydrogenase (XDH) 123 years ago, the oxidation of purines to uric acid via the XDH pathway has been recognized as a central route in purine metabolism. Two recent studies now describe a previously unknown anaerobic uric acid degradation pathway in gut bacteria, highlighting its contribution to systemic urate homeostasis and its therapeutic promise for hyperuricemia and gout.File in questo prodotto:
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