A penicillin-resistant group B streptococcal (GBS) strain was identified in Italy, after isolation from the blood culture of a patient in their 80s with comorbidities. The isolate was multidrug-resistant and demonstrated by genome sequencing to be of serotype Ia, sequence type 23, and to possess the alp1 gene. Known and new point mutations were detected in the penicillin-binding-protein genes 2a and 2x. Although sporadic, penicillin-resistance in GBS is a serious concern for prophylaxis and therapy, so continued GBS surveillance remains important.
First case of penicillin-resistant Streptococcus agalactiae (group B Streptococcus) isolated from an adult patient in Italy, February 2026 / Creti, R., Gherardi, G., Imperi, M., Zappavigna, A., Tocci, G., Rossi, N., Trapani, F., Alfarone, G., Marani, I., Palamara, A.T., Lo Cascio, G.. - In: EUROSURVEILLANCE. - ISSN 1025-496X. - 31:20(2026). [10.2807/1560-7917.ES.2026.31.20.2600374]
First case of penicillin-resistant Streptococcus agalactiae (group B Streptococcus) isolated from an adult patient in Italy, February 2026
Rossi N.;Lo Cascio G.
2026-01-01
Abstract
A penicillin-resistant group B streptococcal (GBS) strain was identified in Italy, after isolation from the blood culture of a patient in their 80s with comorbidities. The isolate was multidrug-resistant and demonstrated by genome sequencing to be of serotype Ia, sequence type 23, and to possess the alp1 gene. Known and new point mutations were detected in the penicillin-binding-protein genes 2a and 2x. Although sporadic, penicillin-resistance in GBS is a serious concern for prophylaxis and therapy, so continued GBS surveillance remains important.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
