Background: The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown. Objective: To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis. Methods: CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing-remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls. Results: CSF amounts of 78kDa HLA-G dimers were more frequent in RRMS than in inflammatory (p<0.01) and non-inflammatory controls (p<0.001) and in magnetic resonance imaging (MRI) inactive than in MRI active RRMS (p<0.00001). Conclusion: Our findings suggest that HLA-G dimers may be implicated in termination of inflammatory response occurring in MS.

Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis / Fainardi, E., Bortolotti, D., Bolzani, S., Castellazzi, M., Tamborino, C., Roversi, G., Baldi, E., Caniatti, M.L., Casetta, I., Gentili, V., Granieri, E., Rizzo, R., Tola, M.R., Dallocchio, F., Bellini, T., Rotola, A., Di Luca, D., Seraceni, S., Contini, C., Sabbioni, S., et al.. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 22:2(2016), pp. 245-249. [10.1177/1352458515590647]

Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis

Terzano G.;Granella F.;Vitetta F.;Montepietra S.;Immovilli P.;Pesci I.;Guareschi A.;
2016-01-01

Abstract

Background: The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown. Objective: To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis. Methods: CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing-remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls. Results: CSF amounts of 78kDa HLA-G dimers were more frequent in RRMS than in inflammatory (p<0.01) and non-inflammatory controls (p<0.001) and in magnetic resonance imaging (MRI) inactive than in MRI active RRMS (p<0.00001). Conclusion: Our findings suggest that HLA-G dimers may be implicated in termination of inflammatory response occurring in MS.
2016
Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis / Fainardi, E., Bortolotti, D., Bolzani, S., Castellazzi, M., Tamborino, C., Roversi, G., Baldi, E., Caniatti, M.L., Casetta, I., Gentili, V., Granieri, E., Rizzo, R., Tola, M.R., Dallocchio, F., Bellini, T., Rotola, A., Di Luca, D., Seraceni, S., Contini, C., Sabbioni, S., et al.. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 22:2(2016), pp. 245-249. [10.1177/1352458515590647]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/3070045
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