Fetal surgery offers valuable opportunities to address severe congenital disabilities, yet accurate evaluation of fetal physiological changes during in utero procedures to mitigate the risk of operative complications remains an unmet need. Conventional unimodal approaches lack predictive value, specificity and compatibility with minimally invasive interventions. Here we present a bioelectronic system featuring a multimodal, steerable filamentary probe that interfaces directly with the fetus in utero, enabling reliable and minimally invasive monitoring of various physiological parameters. Integrated soft robotic actuators ensure consistent contact through controlled navigation and force delivery, creating a gentle and secure interface with delicate fetal surfaces. In a sheep fetal surgery model, the multifunctional probe effectively monitored in utero conditions during fetoscopic surgeries, detecting fetal bradycardia, hypoxia and hypothermia, potentially informing for early intervention. Experimental results on rodents and large animal fetuses demonstrate potential for direct translation to human use. This system offers continuous, comprehensive fetal monitoring, addressing gaps in current clinical practices, and provides real-time insights during fetal surgeries.
A filamentary soft robotic probe for multimodal in utero monitoring of fetal health / Bai, H., Zhou, J., Wu, M., Papastefan, S., Li, X., Zhang, H., Zhao, K., Zhang, Z., Ouyang, W., Redden, C.R., Alhajjat, A.M., Wang, H., Zhou, Y., Madsen, K., Li, S., Efimov, A.I., Ma, K., Kovacs, L., Patel, S., Liesman, D.R., et al.. - In: NATURE BIOMEDICAL ENGINEERING. - ISSN 2157-846X. - (2026). [10.1038/s41551-025-01605-3]
A filamentary soft robotic probe for multimodal in utero monitoring of fetal health
Garziera, Rinaldo;
2026-01-01
Abstract
Fetal surgery offers valuable opportunities to address severe congenital disabilities, yet accurate evaluation of fetal physiological changes during in utero procedures to mitigate the risk of operative complications remains an unmet need. Conventional unimodal approaches lack predictive value, specificity and compatibility with minimally invasive interventions. Here we present a bioelectronic system featuring a multimodal, steerable filamentary probe that interfaces directly with the fetus in utero, enabling reliable and minimally invasive monitoring of various physiological parameters. Integrated soft robotic actuators ensure consistent contact through controlled navigation and force delivery, creating a gentle and secure interface with delicate fetal surfaces. In a sheep fetal surgery model, the multifunctional probe effectively monitored in utero conditions during fetoscopic surgeries, detecting fetal bradycardia, hypoxia and hypothermia, potentially informing for early intervention. Experimental results on rodents and large animal fetuses demonstrate potential for direct translation to human use. This system offers continuous, comprehensive fetal monitoring, addressing gaps in current clinical practices, and provides real-time insights during fetal surgeries.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
