Biological applications of coordination complexes are becoming one of the focal attractions for researchers. These types of metal-organic frameworks with exceptional stability have played a significant role in the realm of anticancer drug discovery. Moving in to this idea, one trinuclear ZnII complex [(L)2Zn3(H2O)4].(H2O).(NO3) (1) and one 1-dimensional CdII coordination polymer, [(L)Cd2Cl3]n (2), (where L is the deprotonated form of quinoline based ligand, H2L) are designed and systematically characterized by different spectroscopic techniques along with the structural studies. The interaction of ZnII and CdII ions with the ligand was studied by measuring the intrinsic fluorescent intensity of the ligand before and after the addition of metal ions. Between both complexes, complex 2 exhibited excellent anti-cancer activity against MCF 7 (breast cancer) cell line [IC50: 98.07 μM] and its cytotoxic effect was evaluated against normal human peripheral blood mononuclear cells (PBMC) and RBCs. The study of alpha and beta-cyclodextrin inclusion with these two complexes is explored along with the host-guest stoichiometry and binding mode calculations.
Quinoline based ZnII and CdII complexes: Exploring structural, photophysical, supramolecular interactions and anticancer activities / Chatterjee, A.; Das, D.; Chakraborty, P.; Kumar, B.; Mandal, S.; Rizzoli, C.; Mahapatra, C.; Bhattacharyya, S.; Dey, S. K.. - In: JOURNAL OF MOLECULAR STRUCTURE. - ISSN 0022-2860. - 1340:142546(2025). [10.1016/j.molstruc.2025.142546]
Quinoline based ZnII and CdII complexes: Exploring structural, photophysical, supramolecular interactions and anticancer activities
Rizzoli C.;
2025-01-01
Abstract
Biological applications of coordination complexes are becoming one of the focal attractions for researchers. These types of metal-organic frameworks with exceptional stability have played a significant role in the realm of anticancer drug discovery. Moving in to this idea, one trinuclear ZnII complex [(L)2Zn3(H2O)4].(H2O).(NO3) (1) and one 1-dimensional CdII coordination polymer, [(L)Cd2Cl3]n (2), (where L is the deprotonated form of quinoline based ligand, H2L) are designed and systematically characterized by different spectroscopic techniques along with the structural studies. The interaction of ZnII and CdII ions with the ligand was studied by measuring the intrinsic fluorescent intensity of the ligand before and after the addition of metal ions. Between both complexes, complex 2 exhibited excellent anti-cancer activity against MCF 7 (breast cancer) cell line [IC50: 98.07 μM] and its cytotoxic effect was evaluated against normal human peripheral blood mononuclear cells (PBMC) and RBCs. The study of alpha and beta-cyclodextrin inclusion with these two complexes is explored along with the host-guest stoichiometry and binding mode calculations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
