The TBD (1,3,5-triazabicyclodec-5-ene) assisted three-component carbonylation of pyridine-2-methana- mines is documented by means of CO2 as a benign CO surrogate. The redox-neutral methodology enables the re- alization of densely functionalized imidazo-pyridinones in high yields (up to 93%) and excellent chemoselectivity. Combined computational and experimental investigations revealed an unprecedented RCOCl/TBD concerted electro- philic activation of carbon dioxide.
Redox-Neutral Metal-Free Three-Component Carbonylative Dearomatization of Pyridine Derivatives with CO2 / Cerveri, Alessandro; Pace, Stefano; Monari, Magda; Lombardo, Marco; Bandini, Marco. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 25:67(2019), pp. 15272-15276. [10.1002/chem.201904359]
Redox-Neutral Metal-Free Three-Component Carbonylative Dearomatization of Pyridine Derivatives with CO2
Alessandro Cerveri;
2019-01-01
Abstract
The TBD (1,3,5-triazabicyclodec-5-ene) assisted three-component carbonylation of pyridine-2-methana- mines is documented by means of CO2 as a benign CO surrogate. The redox-neutral methodology enables the re- alization of densely functionalized imidazo-pyridinones in high yields (up to 93%) and excellent chemoselectivity. Combined computational and experimental investigations revealed an unprecedented RCOCl/TBD concerted electro- philic activation of carbon dioxide.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
