A new Gastropanel quick test for non-invasive diagnosys in dyspeptic patients. The first experience in primary care setting in North East Italy

Background: Gastropanel is a non-invasive serological test based on Pepsinogens, Gastrin 17, IgG against Hp. Aim of the study: To assess the clinical usefulness of a new quick gastropanel test in a sample of dyspeptic patients in primary care setting. Methods: The GastroPanel® quick test (Biohit Finland), is a rapid lateral flow immunochromatographic POCT test. The results could be available in fifteen minutes. Patient's Population: One hundred and eighty-eight (76 M, 112 F) dyspeptic patients were investigated by using  serum pepsinogens, gastrin 17 and IgG against (quick Gastropanel Test). Results: Patients were singled out as follows: 1) Functional Dyspepsia (72 pts); 2) GERD (40 pts) 3) GERD under PPIs (37 pts), 4) Non-Atrophic Gastritis Hp + (29 pts), 5 Autoimmune Atrophic Gastritis (6 pts), 6) Multifocal Atrophicc Gastritis (4 pts). PGI: the greatest increase in patients on PPIs therapy (148.1 mg/L; p<0.0001), a more moderate increase in Hp patients (116.8 mg/L; p<0.001 and a significant decrease in AAG groups (29.4 mg/L; p<0.0001) and MAG (28.5 mg/L; p<0.0001). PGII: an increase in PPIs users (28.2 mg/L; p<0.001) and in Hp positive subjects (26.0 mg/L; p<0.001). G17: low in GERD subjects (1.8 pmol/L; p<0.01). Subjects on PPIs show elevated levels (15.7 pmol/L; p<0.0001). Patients with AAG show increased G17 (9.2 pmol/L; p<0.05), MAG subjects show low levels (2.0 pmol/L; p<0.01). Conclusion: This study show that the new quick gastropanel test is a reliable method also in a non-laboratory setting. Therefore, it could be proposed as the first approach in primary care.