Late-Onset Neonatal Sepsis (LOS) is a rare condition, involving widespread infection, immune disruption, organ dysfunction, and often death. Because exposure to pathogens is not completely preventable, identifying susceptibility factors is critical to characterizing the pathophysiology and developing interventions. Prior studies demonstrated both genetics and infant sex influence susceptibility. Our study was designed to identify LOS associated genetic variants.

Late-onset neonatal sepsis: genetic differences by sex and involvement of the NOTCH pathway / Ciesielski, Timothy H; Zhang, Xueyi; Tacconelli, Alessandra; Lutsar, Irja; De Cabre, Vincent Meiffredy; Roilides, Emmanuel; Ciccacci, Cinzia; Borgiani, Paola; Scott, William K; Williams, Scott M; Sirugo, Giorgio; Esposito, Susanna. - In: PEDIATRIC RESEARCH. - ISSN 1530-0447. - (2022). [10.1038/s41390-022-02114-8]

Late-onset neonatal sepsis: genetic differences by sex and involvement of the NOTCH pathway

Esposito, Susanna
2022-01-01

Abstract

Late-Onset Neonatal Sepsis (LOS) is a rare condition, involving widespread infection, immune disruption, organ dysfunction, and often death. Because exposure to pathogens is not completely preventable, identifying susceptibility factors is critical to characterizing the pathophysiology and developing interventions. Prior studies demonstrated both genetics and infant sex influence susceptibility. Our study was designed to identify LOS associated genetic variants.
2022
Late-onset neonatal sepsis: genetic differences by sex and involvement of the NOTCH pathway / Ciesielski, Timothy H; Zhang, Xueyi; Tacconelli, Alessandra; Lutsar, Irja; De Cabre, Vincent Meiffredy; Roilides, Emmanuel; Ciccacci, Cinzia; Borgiani, Paola; Scott, William K; Williams, Scott M; Sirugo, Giorgio; Esposito, Susanna. - In: PEDIATRIC RESEARCH. - ISSN 1530-0447. - (2022). [10.1038/s41390-022-02114-8]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/3042714
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