IRIS

Background: Tirzepatide, a dual incretin agonist of the glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors, has favorable effects on glycemic control and body weight. The effects on cardiovascular outcomes are uncertain. Methods: We conducted an active-comparator-controlled, double-blind, noninferiority trial in which patients with type 2 diabetes and atherosclerotic cardiovascular disease were randomly assigned in a 1:1 ratio to receive a weekly subcutaneous injection of tirzepatide (up to 15 mg) or dulaglutide (1.5 mg), an agent that has been shown to reduce the incidence of cardiovascular events. The primary end point was a composite of death from cardiovascular causes, myocardial infarction, or stroke and was tested for noninferiority of tirzepatide to dulaglutide with a margin of 1.05 for the upper limit of the 95.3% confidence interval for the hazard ratio. An upper limit of less than 1.00 was considered to indicate superiority of tirzepatide to dulaglutide. Results: A total of 13,299 patients underwent randomization; 134 were subsequently excluded because they did not meet inclusion criteria. The modified intention-to-treat population thus included 6586 patients in the tirzepatide group and 6579 in the dulaglutide group. The mean (±SD) age of the patients was 64.1±8.8 years, 29.0% were women, the mean body-mass index (the weight in kilograms divided by the square of the height in meters) was 32.6±5.5, the mean glycated hemoglobin level was 8.4±0.9%, and the mean duration of diabetes was 14.7±8.8 years. A primary end-point event occurred in 801 patients (12.2%) in the tirzepatide group and 862 (13.1%) in the dulaglutide group (hazard ratio, 0.92; 95.3% confidence interval, 0.83 to 1.01; P = 0.003 for noninferiority; P = 0.09 for superiority). The incidence of adverse events appeared to be similar in the two groups, although more gastrointestinal adverse events were observed in the tirzepatide group. Conclusions: Among patients with type 2 diabetes and atherosclerotic cardiovascular disease, tirzepatide was noninferior to dulaglutide with respect to a composite of death from cardiovascular causes, myocardial infarction, or stroke. (Funded by Eli Lilly; SURPASS-CVOT ClinicalTrials.gov number, NCT04255433.).

Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes / Stephen J., Nicholls; Imre, Pavo; Deepak L., Bhatt; John B., Buse; Stefano, Del Prato; Steven E., Kahn; A. Michael, Lincoff; Darren K., Mcguire; Debra, Miller; Michael A., Nauck; Hiroshi, Nishiyama; Steven E., Nissen; Naveed, Sattar; Govinda, Weerakkody; Russell J., Wiese; Bernard, Zinman; Sophia, Zoungas; Jan, Basile; Melanie J., Davies; Francesco, Giorgino; Monika, Kellerer; Linong, Ji; Tamas, Varkonyi; Venu, Menon; Jonathan C., Broder; Alan, Herschtal; David, D'Alessio; Mackinnon, Ignacio; Zaidman, Cesar; Romeo, Alejandra; Vico, Marisa; Abalos, Franklin; Sassone, Sonia; Aizenberg, Diego; Majul, Claudio; Lanchiotti, Paulina; Sessa, Horacio; Chertkoff, Alejandro; Waitman, Jorge; Dominguez, Andrea; Montaña, Oscar; Nardone, Lucrecia; Fretes, José; Sicer, Maximiliano; Frechtel, Gustavo; Serra, Leonardo; Gutnisky, Lucas; Maldonado, Natacha; Prado, Aldo; Steinacher, Maria; Ulla, Maria; Gelersztein, Elizabeth; Saavedra, Silvia; Valdez, Maria; Koretzky, Martin; Gorban De Lapertosa, Silvia; Vallejos, Julio; Alberto Carrozza, Diego; Li Yee, Ming; D'Emden, Michael; Rahman, Atifur; Hamilton, Andrew; Morbey, Claire; Ekinci, Elif; Caterson, Ian; Williams, Kathryn; Hau Choy, Kay; Colquhoun, David; Purnell, Peter; Sangla, Kunwarjit; Davis, Timothy; Ho, Jui; Phillips, Liza; Pape, Alexia; Worthley, Matthew; Nicholls, Stephen; Cooke, Duncan; Hanusch, Ursula; Ludvik, Bernhard; Sourij, Harald; Stulnig, Thomas; Stechemesser, Lars; Kautzky-Willer, Alexandra; Nobels, Frank; Coremans, Peter; Debroye, Corinne; De Block, Christophe; Verhaegen, Ann; Mertens, Ann; Duyck, Francis; Taes, Youri; Crenier, Laurent; Vercammen, Chris; Winne, Linsey; Vanhaverbeke, Gerd; Radermecker, Regis; Cools, Frank; Franco, Denise; Cezar Santomauro Junior, Augusto; Salles, Joao; Balabem Alves, Breno; Rea, Rosangela; Cercato, Cintia; Saraiva, Jose; Helena Vidotti, Maria; Augusto, Gustavo; Hissa, Miguel; Russo, Luis; Henrique Canani, Luis; Santos, Queulla; De Oliveira, Gabriela; Pereira, Márcio; Dumas, Richard; Abitbol, Alexander; Bajaj, Harpreet; Woo, Vincent; Liu, Selina; Noronha, Luis; Twum-Barima, David; Khandwala, Hasnain; Chehayeb, Raja; Shukla, Dinkar; Cha, James; Constance, Christian; Tailor, Chetna; Filteau, Pierre; Vallieres, Gerald; Schlosser, Robert; Alasaad, Hani; Hartleib, Michael; Conway, James; Yip, Churn-Ern; Elliott, Thomas; Jones, Michael; Pliamm, Lew; Ajala, Buki; Shekhar Pandey, A; Aggarwal, Naresh; Dzongowski, Peter; O'Mahony, John; Gupta, Anil; Verma, Subodh; Shen, Aidong; Zheng, Ziqi; Jiang, Jie; Dong, Xiaoying; Tang, Xulei; Zhang, Junqing; Dong, Xiaolin; Peng, Jianqiang; Ma, Changsheng; Ji, Linong; Guo, Hui; Ma, Jianhua; Dong, Yugang; Sun, Yuemin; Ma, Genshan; Xu, Biao; Jun Huang, Wen; Lu, Weiping; Yuan, Guoyue; Lu, Yibing; Cheng, Zhifeng; Liu, Ying; Bai, Feng; Yang, Ping; Kopecka, Sarka; Bartaskova, Dagmar; Edelsberger, Tomas; Malicherova, Emilia; Hron, Jakub; Pelikanova, Michala; Diepoltova, Barbora; Vachova, Alena; Ceska, Richard; Sejvlova, Petra; Cariou, Bertrand; Bully, Chantal; Agopian, Bermione; Potier, Louis; Penfornis, Alfred; Verges, Bruno; Gourdy, Pierre; Larroumet, Alice; Gautier, Jean-Francois; Guerci, Bruno; Dupuy, Olivier; Sauter, Joachim; Busch, Klaus; Rose, Ludger; Simon, Joerg; Kraft, Martina; Segner, Alexander; Hagenow, Andreas; Wenzl-Bauer, Veronika; Milek, Karsten; Lee-Barkey, Young-Hee; Schaum, Thomas; Dahl, Dominik; Kempe, Hans-Peter; Meyhöfer, Svenja; Marck, Cornelia; Tews, Dietrich; Luedemann, Joerg; Klausmann, Gerhard; Simon-Wagner, Ilka; Derwahl, Karl-Michael; Sarnighausen, Hans-Eckart; Paschen, Bjoern; Schlichthaar, Heike; Zeller, Helga; Weigmann, Ingo; Denger, Ralf; Marcel Serban, Pavel; Bieler, Tasso; Kosch, Christine; Jung, Thomas; Segiet, Thomas; Kellerer, Monika; Lorra, Babette; Becker, Bernd; Braun, Hermann; Jacob, Stephan; Schwarz, Toralf; Henkel, Elena; Taeschner, Heidrun; Schaefer, Axel; Mehltretter, Kai; Witzel, Peter; Hartard, Manfred; Stahl, Hans-Detlev; Weimer, Joachim; Haas, Johannes; Winkelmann, Bernhard; Stephan, Uta; Pagkalos, Emmanouil; Tzatzagou, Glykeria; Benroubi, Marianna; Kotsa, Kalliopi; Mouslech, Zadalla; Markou, Athina; Lambadiari, Vaia; Bargiota, Alexandra; Zografou, Ioanna; Doupis, John; Noori, Ebrahim; Pauer, Jozsef; Kesmarki, Nora; Bujtor, Zoltan; Wudi, Krisztina; Salamon, Csaba; Kajetan, Miklos; Beke, Eleonora; Berhes, Istvan; Mohácsi, Attila; Hevesi, Judit; Varkonyi, Tamas; Petro, Gizella; Revesz, Katalin; Pap, Gizella; Pall, Denes; Tibor Kis, Janos; Kaul, Upendra; Mohan, Viswanathan; Mehta, Ashwani; Sethi, Bipin; Mehta, Vimal; Banerjee, Suvro; Ambuj, Roy; Bandgar, Tushar; Parikh, Keyur; Shah, Parag; Bhagwat, Nikhil; Julka, Sandeep; Gandhi, Pramod; Shamanna, Paramesh; Mazen, Elias; Tirosh, Amir; Roguin, Ariel; Hochberg, Irit; Zornitzki, Taiba; Adawi, Faiad; Dicker, Dror; Sofer, Yael; Tsur, Anat; Darawsha, Mahmud; Liberty, Idit; Leibowitz, David; Bashkin, Amir; Vishlitzky, Victor; Sabbah, Muhammad; Munter, Gavriel; Durst, Ronen; Yosefy, Chaim; Aharon Hananel, Genya; Francis, Adi; Grossman, Alon; Shechter, Michael; Dobrecky Mery, Idit; Wainstein, Julio; Haddad, Elie; Picconi, Fabiana; Zoppini, Giacomo; Esposito, Katherine; Orsi, Emanuela; Mannucci, Edoardo; Giaccari, Andrea; Pagotto, Uberto; Giorgino, Francesco; Giordano, Carla; Lauro, Davide; De Cata, Pasquale; Arturi, Franco; Trevisan, Roberto; Tonolo, Giancarlo; Dei Cas, Alessandra; Genovese, Stefano; Consoli, Agostino; Romeo, Francesco; Del Prato, Stefano; Frittitta, Lucia; Sato, Nobuyuki; Onishi, Yukiko; Onaka, Haruhiko; Kiyosue, Arihiro; Fukushima, Yasushi; Yamasaki, Yoshimitsu; Jinnouchi, Hideaki; Iwanaga, Yoshitaka; Sueyoshi, Atsushi; Bayram Llamas, Edmundo; Nevarez, Luis; Fajardo Campos, Pedro; Alpizar Salazar, Melchor; Vidrio, Maricela; Banda Elizondo, Ramiro; Lopez, Agustin; Sauque Reyna, Leobardo; García Hernández, Pedro; Núñez Fragoso, Juan; Alberto García Cantú, Elías; Gonzalez Galvez, Guillermo; Pascoe, Sara; Medina, Carlos; Alejandro Stobschinski De Alba, Carlos; De Los Rios Ibarra, Manuel; Arechavaleta Granell, Maria; Calvo Vargas, Cesar; Gerardo Gonzalez Gonzalez, Jose; Pelayo Orozco, Emilia; Antonio Llamas Esperon, Guillermo; Violante Ortiz, Rafael; Ramirez Diaz, Santiago; Alcocer Gamba, Marco; Lopez Rosas, Enrique; Kuijper, Aaf; Abbink, Evertine; Alhakim, Mazin; Drost, J; Josephus Maria Oude Ophuis, Anthonius; Houtgraaf, Jaco; Nieuwdorp, Max; Van Eck, Martijn; Nierop, Pieter; Van Raalte, Daniel; Bemelmans, Remy; Kooy, Adriaan; Constandse, Jan; Kievit, Chris; Monajemi, Houshang; Jaspers Focks, Jeroen; Spiering, Wilko; Broeyer, Freerk; Rudzki, Henryk; Jozefowska, Malgorzata; Lukaszewicz, Monika; Szyprowska, Ewa; Jusiak, Katarzyna; Modzelewska, Anna; Sowinski, Dariusz; Matyjaszek-Matuszek, Beata; Skokowska, Ewa; Pankowska, Ewa; Kwiatkowska, Magdalena; Opiela, Jaroslaw; Krzyzagorska, Ewa; Laszewska, Grazyna; Witek, Robert; Pisarczyk-Wiza, Dorota; Tiuryn-Petrulewicz, Agnieszka; Stasinska, Teresa; Madej, Andrzej; Mindrescu, Nicoleta; Ciomos, Daniela; Pletea, Noemi; Valerica, Nafornita; Popa, Bogdan; Neacsu, Valentina; Onaca, Adriana; Diana Hortensia, Barbonta; Vacaru, Georgeta; Popescu, Alexandrina; Mihaela Vladu, Ionela; Cosma, Dana; Morosanu, Magdalena; Guja, Cristian; Pop, Lavinia; Pintilei, Ella; Pascu, Marlena; Gutu, Olimpia; Negrisanu, Gabriela; Thury-Burileanu, Amalia; Chazova, Irina; Khalimov, Yury; Kunitsyna, Marina; Vorokhobina, Natalia; Yakushin, Sergey; Dvoryashina, Irina; Samoylova, Julia; Glinkina, Irina; Mkrtumyan, Ashot; Markova, Tatiana; Vorobyev, Sergey; Petunina, Nina; Khokhlov, Alexander; Dreval, Alexander; Kharakhulakh, Marina; Ipatko, Irina; Ershova, Olga; Filippov, Evgeny; Ermakova, Polina; Startseva, Maria; Gonchar, Natalia; Galstyan, Gagik; Bondar, Irina; Demidova, Irina; Litvin, Alexander; Drapkina, Oxana; Merciakova, Martina; Teplanova, Miriam; Kubincova, Ludmila; Zobokova, Barbora; Macko, Marek; Zakovicova, Eva; Lachova, Beata; Gabrisova, Alena; Tomasova, Livia; Sosovec, Dalibor; Lee, Joonyub; Myung Yu, Jae; Wan Lee, Byung; Jeung Ahn, Kyu; Min Cho, Young; Namgoong, Ilseong; Soon Kim, Hye; Hee Chung, Choon; Je Lee, Woo; Gon Kim, Sin; Fajardo, Carmen; Ramon Gonzalez-Juanatey, Jose; Beltran Robles, Manuel; Soto Gonzalez, Alfonso; De La Cuesta, Carmen; Jodar Gimeno, Esteban; López De La Torre Casares, Martín; Tinahones Madueno, Francisco; Merino-Torres, Juan; Rivas Fernandez, Margarita; Bellido Guerrero, Diego; Angel Rico Corral, Miguel; Manzano Espinosa, Luis; Carlos Ferrer Garcia, Juan; Mezquita-Raya, Pedro; Botella Serrano, Marta; Garcia Del Rio, Enrique; Delgado, Elias; De Luis Roman, Daniel; Castro, Almudena; Larnefeldt, Hans; Eliasson, Björn; Tengmark, Bengt-Olov; Mooe, Thomas; Eliasson, Ken; Luts, Anders; Sung, Shih-Hsien; Lee, I-Te; Hsieh, I-Chang; Huang, Wei-Fu; Tu, Shih-Te; Chao, Ting-Hsing; Chen, Jung-Fu; Liu, Ming-En; Wang, Ji-Hung; Araz, Mustafa; Sertbas, Meltem; Sezer, Kerem; Yaylali, Guzin; Guney, Engin; Dogruel, Fatma; Celik, Ozlem; Deyneli, Oguzhan; Mert, Meral; Comlekci, Abdurrahman; Saygili, Fusun; Kebabci, Nur; Evren, Bahri; Bilen, Habib; Sargin, Mehmet; Bakiner, Okan; Sari, Ramazan; Canturk, Zeynep; Tuzcu, Alpaslan; Orlenko, Valeriia; Kaydashev, Igor; Berenfus, Vadym; Panina, Svitlana; Prystupa, Lyudmila; Katerenchuk, Vitaliy; Zinych, Olesia; Vlasenko, Maryna; Pashkovska, Nataliia; Pertseva, Nataliia; Vizir, Vadym; Pererva, Larysa; Kopytsya, Mykola; Kuznietsova, Olena; Tseluyko, Vira; Mankovsky, Borys; Reshotko, Dmytro; Serhiyenko, Olexandr; Zlova, Tetiana; Teliatnikova, Zinaida; Postol, Svitlana; Browne, Duncan; Mccrimmon, Rory; Davies, Melanie; Tatovic, Danijela; Garstang, Jonathan; Sathyapalan, Thozhukat; Philip, Sam; Wilding, John; Sharma, Sanjeev; Stephens, Jeffrey; Boyle, James; Gunstone, Anthony; Tan, Anjanette; Chang, Anna; Shlesinger, Yshay; Gangi, Sumana; Bressler, Peter; Aslam, Shamaila; Wiebel, Jaime; Palal, Betsy; Nakhle, Samer; Tripathy, Devjit; Gabriel, John; Lillestol, Michael; Pullman, John; Fitz-Patrick, David; Soufer, Joseph; Agarwal, Shubham; Poremba, John; Tanzer, Adam; Cortes-Maisonet, Gregorio; Smith, Timothy; Wynne, Alan; Comulada-Rivera, Angel; Ortiz-Carrasquillo, Ramon; Schuchard, Timothy; Biscoveanu, Mihaela; Brautigam, Donald; Vazquez-Tanus, Jose; Palchick, Bryce; Bhargava, Anuj; Correia, Marcelo; Samal, Aditya; Busch, Robert; Cavale, Arvind; Oliver, Michael; French, William; Hansen, Darrin; Woolman, Michael; Chow, Christopher; Bitar, Fahed; Chochinov, Ronald; Johnson, David; Soucie, Gary; Boeder, Schafer; Mello, Curtis; Ledger, Gregory; Norwood, Paul; Bailey, Timothy; Gaudiani, Linda; Lee Rabin, Mara; Sivalingam, Kanagaratnam; Madu, Ivy-Joan; Firek, Anthony; Grasch, Anton; Utzschneider, Kristina; Barkhuizen, Andre; Khachikian, Sonalika; Desouza, Cyrus; Youssef, Rasha; Foucauld, Jean; Vedere, Amarnath; Forgosh, Les; Cox, Michael; Suh, David; Singh, Narendra; Odugbesan, Ola; Robbins, David; Mangual Garcia, Michelle; Rodbard, Helena; Brusco, Osvaldo; Ong, Stephen; Koren, Michael; Jabbour, Serge; Chu, James; Rovner, Sergio; Park, Jean; Bode, Bruce; Cole, Jeffrey; Jones, Thomas; Nadar, Venkatesh; Luo, Lan; Canadas, Rafael; Saba, Fadi; Rowell, Jennifer; Cohen, Alan; Haddad, Tariq; Miao, Simeng; Parker, John; Koilpillai, Robinson; Whiles, Rick; Ranadive, Nadakishore; Mills, Richard; Manning, Rickey; Barker, Timothy; Welch, Michelle; Mayfield, Ronald; Ovalle, Fernando; Rasouli, Neda; Chaychi, Leila; Hotchkiss, David; Magee, James; Berk, Martin; Wysham, Carol; Hiten Upadhyay, Shital; Hamdy, Osama; Aroda, Vanita; Bays, Harold; Gonzalez-Orozco, Luis; Sugimoto, Danny; Lupovitch, Steven; Agaiby, John; Fraser, Neil; Christopher Sartore, J; Widicus, Diana; Barzilay, Joshua; Slim, Ahmad; Rosenstock, Julio; Shikuma Lee, Kelsey; Pantalone, Kevin; Hermayer, Kathie; Bekwelem, Wobo; Connery, Lisa; Prier, Kevin; Grena, Paul; Perez, Rodolfo. - In: THE NEW ENGLAND JOURNAL OF MEDICINE. - ISSN 0028-4793. - 393:24(2025), pp. 2409-2420. [10.1056/nejmoa2505928]

Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes

Alessandra Dei Cas;
2025-01-01

Abstract

Background: Tirzepatide, a dual incretin agonist of the glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors, has favorable effects on glycemic control and body weight. The effects on cardiovascular outcomes are uncertain. Methods: We conducted an active-comparator-controlled, double-blind, noninferiority trial in which patients with type 2 diabetes and atherosclerotic cardiovascular disease were randomly assigned in a 1:1 ratio to receive a weekly subcutaneous injection of tirzepatide (up to 15 mg) or dulaglutide (1.5 mg), an agent that has been shown to reduce the incidence of cardiovascular events. The primary end point was a composite of death from cardiovascular causes, myocardial infarction, or stroke and was tested for noninferiority of tirzepatide to dulaglutide with a margin of 1.05 for the upper limit of the 95.3% confidence interval for the hazard ratio. An upper limit of less than 1.00 was considered to indicate superiority of tirzepatide to dulaglutide. Results: A total of 13,299 patients underwent randomization; 134 were subsequently excluded because they did not meet inclusion criteria. The modified intention-to-treat population thus included 6586 patients in the tirzepatide group and 6579 in the dulaglutide group. The mean (±SD) age of the patients was 64.1±8.8 years, 29.0% were women, the mean body-mass index (the weight in kilograms divided by the square of the height in meters) was 32.6±5.5, the mean glycated hemoglobin level was 8.4±0.9%, and the mean duration of diabetes was 14.7±8.8 years. A primary end-point event occurred in 801 patients (12.2%) in the tirzepatide group and 862 (13.1%) in the dulaglutide group (hazard ratio, 0.92; 95.3% confidence interval, 0.83 to 1.01; P = 0.003 for noninferiority; P = 0.09 for superiority). The incidence of adverse events appeared to be similar in the two groups, although more gastrointestinal adverse events were observed in the tirzepatide group. Conclusions: Among patients with type 2 diabetes and atherosclerotic cardiovascular disease, tirzepatide was noninferior to dulaglutide with respect to a composite of death from cardiovascular causes, myocardial infarction, or stroke. (Funded by Eli Lilly; SURPASS-CVOT ClinicalTrials.gov number, NCT04255433.).
2025
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes / Stephen J., Nicholls; Imre, Pavo; Deepak L., Bhatt; John B., Buse; Stefano, Del Prato; Steven E., Kahn; A. Michael, Lincoff; Darren K., Mcguire; Debra, Miller; Michael A., Nauck; Hiroshi, Nishiyama; Steven E., Nissen; Naveed, Sattar; Govinda, Weerakkody; Russell J., Wiese; Bernard, Zinman; Sophia, Zoungas; Jan, Basile; Melanie J., Davies; Francesco, Giorgino; Monika, Kellerer; Linong, Ji; Tamas, Varkonyi; Venu, Menon; Jonathan C., Broder; Alan, Herschtal; David, D'Alessio; Mackinnon, Ignacio; Zaidman, Cesar; Romeo, Alejandra; Vico, Marisa; Abalos, Franklin; Sassone, Sonia; Aizenberg, Diego; Majul, Claudio; Lanchiotti, Paulina; Sessa, Horacio; Chertkoff, Alejandro; Waitman, Jorge; Dominguez, Andrea; Montaña, Oscar; Nardone, Lucrecia; Fretes, José; Sicer, Maximiliano; Frechtel, Gustavo; Serra, Leonardo; Gutnisky, Lucas; Maldonado, Natacha; Prado, Aldo; Steinacher, Maria; Ulla, Maria; Gelersztein, Elizabeth; Saavedra, Silvia; Valdez, Maria; Koretzky, Martin; Gorban De Lapertosa, Silvia; Vallejos, Julio; Alberto Carrozza, Diego; Li Yee, Ming; D'Emden, Michael; Rahman, Atifur; Hamilton, Andrew; Morbey, Claire; Ekinci, Elif; Caterson, Ian; Williams, Kathryn; Hau Choy, Kay; Colquhoun, David; Purnell, Peter; Sangla, Kunwarjit; Davis, Timothy; Ho, Jui; Phillips, Liza; Pape, Alexia; Worthley, Matthew; Nicholls, Stephen; Cooke, Duncan; Hanusch, Ursula; Ludvik, Bernhard; Sourij, Harald; Stulnig, Thomas; Stechemesser, Lars; Kautzky-Willer, Alexandra; Nobels, Frank; Coremans, Peter; Debroye, Corinne; De Block, Christophe; Verhaegen, Ann; Mertens, Ann; Duyck, Francis; Taes, Youri; Crenier, Laurent; Vercammen, Chris; Winne, Linsey; Vanhaverbeke, Gerd; Radermecker, Regis; Cools, Frank; Franco, Denise; Cezar Santomauro Junior, Augusto; Salles, Joao; Balabem Alves, Breno; Rea, Rosangela; Cercato, Cintia; Saraiva, Jose; Helena Vidotti, Maria; Augusto, Gustavo; Hissa, Miguel; Russo, Luis; Henrique Canani, Luis; Santos, Queulla; De Oliveira, Gabriela; Pereira, Márcio; Dumas, Richard; Abitbol, Alexander; Bajaj, Harpreet; Woo, Vincent; Liu, Selina; Noronha, Luis; Twum-Barima, David; Khandwala, Hasnain; Chehayeb, Raja; Shukla, Dinkar; Cha, James; Constance, Christian; Tailor, Chetna; Filteau, Pierre; Vallieres, Gerald; Schlosser, Robert; Alasaad, Hani; Hartleib, Michael; Conway, James; Yip, Churn-Ern; Elliott, Thomas; Jones, Michael; Pliamm, Lew; Ajala, Buki; Shekhar Pandey, A; Aggarwal, Naresh; Dzongowski, Peter; O'Mahony, John; Gupta, Anil; Verma, Subodh; Shen, Aidong; Zheng, Ziqi; Jiang, Jie; Dong, Xiaoying; Tang, Xulei; Zhang, Junqing; Dong, Xiaolin; Peng, Jianqiang; Ma, Changsheng; Ji, Linong; Guo, Hui; Ma, Jianhua; Dong, Yugang; Sun, Yuemin; Ma, Genshan; Xu, Biao; Jun Huang, Wen; Lu, Weiping; Yuan, Guoyue; Lu, Yibing; Cheng, Zhifeng; Liu, Ying; Bai, Feng; Yang, Ping; Kopecka, Sarka; Bartaskova, Dagmar; Edelsberger, Tomas; Malicherova, Emilia; Hron, Jakub; Pelikanova, Michala; Diepoltova, Barbora; Vachova, Alena; Ceska, Richard; Sejvlova, Petra; Cariou, Bertrand; Bully, Chantal; Agopian, Bermione; Potier, Louis; Penfornis, Alfred; Verges, Bruno; Gourdy, Pierre; Larroumet, Alice; Gautier, Jean-Francois; Guerci, Bruno; Dupuy, Olivier; Sauter, Joachim; Busch, Klaus; Rose, Ludger; Simon, Joerg; Kraft, Martina; Segner, Alexander; Hagenow, Andreas; Wenzl-Bauer, Veronika; Milek, Karsten; Lee-Barkey, Young-Hee; Schaum, Thomas; Dahl, Dominik; Kempe, Hans-Peter; Meyhöfer, Svenja; Marck, Cornelia; Tews, Dietrich; Luedemann, Joerg; Klausmann, Gerhard; Simon-Wagner, Ilka; Derwahl, Karl-Michael; Sarnighausen, Hans-Eckart; Paschen, Bjoern; Schlichthaar, Heike; Zeller, Helga; Weigmann, Ingo; Denger, Ralf; Marcel Serban, Pavel; Bieler, Tasso; Kosch, Christine; Jung, Thomas; Segiet, Thomas; Kellerer, Monika; Lorra, Babette; Becker, Bernd; Braun, Hermann; Jacob, Stephan; Schwarz, Toralf; Henkel, Elena; Taeschner, Heidrun; Schaefer, Axel; Mehltretter, Kai; Witzel, Peter; Hartard, Manfred; Stahl, Hans-Detlev; Weimer, Joachim; Haas, Johannes; Winkelmann, Bernhard; Stephan, Uta; Pagkalos, Emmanouil; Tzatzagou, Glykeria; Benroubi, Marianna; Kotsa, Kalliopi; Mouslech, Zadalla; Markou, Athina; Lambadiari, Vaia; Bargiota, Alexandra; Zografou, Ioanna; Doupis, John; Noori, Ebrahim; Pauer, Jozsef; Kesmarki, Nora; Bujtor, Zoltan; Wudi, Krisztina; Salamon, Csaba; Kajetan, Miklos; Beke, Eleonora; Berhes, Istvan; Mohácsi, Attila; Hevesi, Judit; Varkonyi, Tamas; Petro, Gizella; Revesz, Katalin; Pap, Gizella; Pall, Denes; Tibor Kis, Janos; Kaul, Upendra; Mohan, Viswanathan; Mehta, Ashwani; Sethi, Bipin; Mehta, Vimal; Banerjee, Suvro; Ambuj, Roy; Bandgar, Tushar; Parikh, Keyur; Shah, Parag; Bhagwat, Nikhil; Julka, Sandeep; Gandhi, Pramod; Shamanna, Paramesh; Mazen, Elias; Tirosh, Amir; Roguin, Ariel; Hochberg, Irit; Zornitzki, Taiba; Adawi, Faiad; Dicker, Dror; Sofer, Yael; Tsur, Anat; Darawsha, Mahmud; Liberty, Idit; Leibowitz, David; Bashkin, Amir; Vishlitzky, Victor; Sabbah, Muhammad; Munter, Gavriel; Durst, Ronen; Yosefy, Chaim; Aharon Hananel, Genya; Francis, Adi; Grossman, Alon; Shechter, Michael; Dobrecky Mery, Idit; Wainstein, Julio; Haddad, Elie; Picconi, Fabiana; Zoppini, Giacomo; 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Parker, John; Koilpillai, Robinson; Whiles, Rick; Ranadive, Nadakishore; Mills, Richard; Manning, Rickey; Barker, Timothy; Welch, Michelle; Mayfield, Ronald; Ovalle, Fernando; Rasouli, Neda; Chaychi, Leila; Hotchkiss, David; Magee, James; Berk, Martin; Wysham, Carol; Hiten Upadhyay, Shital; Hamdy, Osama; Aroda, Vanita; Bays, Harold; Gonzalez-Orozco, Luis; Sugimoto, Danny; Lupovitch, Steven; Agaiby, John; Fraser, Neil; Christopher Sartore, J; Widicus, Diana; Barzilay, Joshua; Slim, Ahmad; Rosenstock, Julio; Shikuma Lee, Kelsey; Pantalone, Kevin; Hermayer, Kathie; Bekwelem, Wobo; Connery, Lisa; Prier, Kevin; Grena, Paul; Perez, Rodolfo. - In: THE NEW ENGLAND JOURNAL OF MEDICINE. - ISSN 0028-4793. - 393:24(2025), pp. 2409-2420. [10.1056/nejmoa2505928]
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