Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 in Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database

Null, Null; Zalevskaja, K; Ojala, K; Petrov, A; Haupt, S; Sunde, L; Bernstein, I; Jenkins, M A; Aretz, S; Nielsen, M; Capella, G; Balaguer, F; Evans, D G; Burn, J; Holinski-Feder, E; Bertario, L; Bonanni, B; Lindblom, A; Levi, Z; Macrae, F; Winship, I; Plazzer, J-P; Sijmons, R; Laghi, L; Della Valle, A; Heinimann, K; Dębniak, T; Fruscio, R; Lopez-Koestner, F; Alvarez-Valenzuela, K; Katz, L H; Laish, I; Vainer, E; Vaccaro, C; Carraro, D M; Monahan, K; Half, E; Stakelum, A; Winter, D; Kennelly, R; Gluck, N; Sheth, H; Abu-Freha, N; Greenblatt, M; Rossi, B M; Bohorquez, M; Cavestro, G M; Lino-Silva, L S; Horisberger, K; Tibiletti, M G; Do Nascimento, I; Thomas, H; Rossi, N T; Da Silva, L A; Zaránd, A; Ruiz-Bañobre, J; Heuveline, V; Lindberg, L J; Gögenur, I; Hopper, J L; Win, A K; Haile, R W; Lindor, N; Gallinger, S; Le Marchand, L; Newcomb, P A; Figueiredo, J; Buchanan, D D; Thibodeau, S N; Knebel Doeberitz, M V; Loeffler, M; Rahner, N; Schröck, E; Steinke-Lange, V; Schmiegel, W; Vangala, D; Perne, C; Hüneburg, R; Redler, S; Büttner, R; Weitz, J; Pineda, M; Duenas, N; Brunet Vidal, J; Moreira, L; Sánchez, A; Castillo-Iturra, J; Hovig, E; Green, K; Lalloo, F; Hill, J; Crosbie, E; Mints, M; Goldberg, Y; Tjandra, D; Ten Broeke, S W; Kariv, R; Rosner, G; Jain, A; Shah, P; Shah, M; Neffa, F; Esperon, P; Pavicic, W; Torrezan, G T; Bassaneze, T; Martin, C A; Pylvänäinen, K; Möslein, G; Lepistö, A; Mecklin, J-P; Renkonen-Sinisalo, L; Sampson, J R; Dominguez Valentin, M; Møller, P; Seppälä, T T

doi:10.1093/bjs/znaf061

This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.

Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 in Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database / Null, Null; Zalevskaja, K; Ojala, K; Petrov, A; Haupt, S; Sunde, L; Bernstein, I; Jenkins, M A; Aretz, S; Nielsen, M; Capella, G; Balaguer, F; Evans, D G; Burn, J; Holinski-Feder, E; Bertario, L; Bonanni, B; Lindblom, A; Levi, Z; Macrae, F; Winship, I; Plazzer, J-P; Sijmons, R; Laghi, L; Della Valle, A; Heinimann, K; Dębniak, T; Fruscio, R; Lopez-Koestner, F; Alvarez-Valenzuela, K; Katz, L H; Laish, I; Vainer, E; Vaccaro, C; Carraro, D M; Monahan, K; Half, E; Stakelum, A; Winter, D; Kennelly, R; Gluck, N; Sheth, H; Abu-Freha, N; Greenblatt, M; Rossi, B M; Bohorquez, M; Cavestro, G M; Lino-Silva, L S; Horisberger, K; Tibiletti, M G; Do Nascimento, I; Thomas, H; Rossi, N T; Da Silva, L A; Zaránd, A; Ruiz-Bañobre, J; Heuveline, V; Lindberg, L J; Gögenur, I; Hopper, J L; Win, A K; Haile, R W; Lindor, N; Gallinger, S; Le Marchand, L; Newcomb, P A; Figueiredo, J; Buchanan, D D; Thibodeau, S N; Knebel Doeberitz, M V; Loeffler, M; Rahner, N; Schröck, E; Steinke-Lange, V; Schmiegel, W; Vangala, D; Perne, C; Hüneburg, R; Redler, S; Büttner, R; Weitz, J; Pineda, M; Duenas, N; Brunet Vidal, J; Moreira, L; Sánchez, A; Castillo-Iturra, J; Hovig, E; Green, K; Lalloo, F; Hill, J; Crosbie, E; Mints, M; Goldberg, Y; Tjandra, D; Ten Broeke, S W; Kariv, R; Rosner, G; Jain, A; Shah, P; Shah, M; Neffa, F; Esperon, P; Pavicic, W; Torrezan, G T; Bassaneze, T; Martin, C A; Pylvänäinen, K; Möslein, G; Lepistö, A; Mecklin, J-P; Renkonen-Sinisalo, L; Sampson, J R; Dominguez Valentin, M; Møller, P; Seppälä, T T. - In: BRITISH JOURNAL OF SURGERY. - ISSN 0007-1323. - 112:4(2025). [10.1093/bjs/znaf061]