Adenine recognition through triplex-like interactions was explored using clamp-shaped artificial receptor 1, bearing two uracil units and an extended naphthalene scaffold. The requisite binding mode was confirmed for 9-ethyladenine in CDCl3 via NMR investigations. Phase-transfer experiments demonstrated that 1 selectively binds adenosine from an aqueous mixture of four ribonucleosides.
High Affinity Dimeric Uracil-Based Receptor for the Recognition of Adenine Derivatives through Triplex-like Interactions / Volpi, Stefano; Rivi, Nicola; Korom, Saša; Neri, Martina; Knoll, Wolfgang; Corradini, Roberto. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 90:36(2025), pp. 12814-12819. [10.1021/acs.joc.5c01309]
High Affinity Dimeric Uracil-Based Receptor for the Recognition of Adenine Derivatives through Triplex-like Interactions
Volpi, Stefano;Rivi, Nicola;Neri, Martina;Knoll, Wolfgang;Corradini, Roberto
2025-01-01
Abstract
Adenine recognition through triplex-like interactions was explored using clamp-shaped artificial receptor 1, bearing two uracil units and an extended naphthalene scaffold. The requisite binding mode was confirmed for 9-ethyladenine in CDCl3 via NMR investigations. Phase-transfer experiments demonstrated that 1 selectively binds adenosine from an aqueous mixture of four ribonucleosides.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
