We report an unprecedented iron-catalyzed C-H alkylation of widespread benzamides using readily available allenes. The method, based on cheap, nontoxic, and earth abundant iron catalysts, exploits the assistance of removable triazole directing groups to yield a wide array of Z internal olefins, even at room temperature, with excellent stereocontrol, good yields, and broad functional group tolerance.
Z-Selective Iron-Catalyzed C-H Alkylations with Allenes: Access to Stereodefined Olefins / Cattani, S.; Cordovani, F.; Balestri, D.; Oliveira, J. C. A.; Peters, S. E.; Ackermann, L.; Cera, G.. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 27:29(2025), pp. 7950-7955. [10.1021/acs.orglett.5c02274]
Z-Selective Iron-Catalyzed C-H Alkylations with Allenes: Access to Stereodefined Olefins
Cattani S.;Balestri D.;Cera G.
2025-01-01
Abstract
We report an unprecedented iron-catalyzed C-H alkylation of widespread benzamides using readily available allenes. The method, based on cheap, nontoxic, and earth abundant iron catalysts, exploits the assistance of removable triazole directing groups to yield a wide array of Z internal olefins, even at room temperature, with excellent stereocontrol, good yields, and broad functional group tolerance.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
