Abstract: This national expert-based Delphi-consensus aims at formulating recommendations on the management of dementia care in Italy. This effort seems important and timely given in light of a new scenario arising from a new biological definition of Alzheimer’s disease (AD) and the availability of disease-modifying treatments (DMTs). Methods: the Steering Committee of the Italian Neurological Society for dementia (SINdem) created appropriate statements. Invited SINdem experts were requested to vote on the statements according to a modified three-round Delphi method. Only those statements reaching Grade A (full agreement ≥ 75%) or B (overall agreement ≥ 80% and full disagreement < 5%) were included in the final document. Round answers’ consistency was graded using the Cohen’s k and within-class correlation coefficient. Results: Forty-six experts voted on 20 statements, which focused on the following aspects: i) organization of care services from early diagnosis to the management of advanced clinical stages; ii) access to biomarkers for a biological diagnosis of AD; iii) requirements necessary for the administration of DMTs; iv) main actors and pathways for the management of patients suffering from cognitive disorders. At the end of the process, 4 statements (20%) received a Grade A consensus, while 16 (80%) reached a Grade B consensus. Although the responses reflect heterogeneity among Italian regions, there was a fair degree of consistency for all statements. Conclusion: The high strength of this expert-based Delphi-consensus may offer guidance for improving the patient’s journey of individuals with cognitive decline from a biological diagnosis to DMTs administration and may possibly offer hints to the Health Systems on dementia.
Towards a new Value-based scenario for the management of dementia in Italy: a SINdem delphi consensus study / Marra, C.; Beccia, F.; Caffarra, P.; L'Abbate, F.; Agosta, F.; Benussi, A.; Bonanni, L.; Bruni, A. C.; Bruno, G.; Cappa, S. F.; Cerami, C.; Di Lorenzo, F.; Ferrarese, C.; Galimberti, D.; Guarnieri, B.; Mariani, C.; Nacmias, B.; Pantoni, L.; Piccoli, T.; Perani, D.; Rainero, I.; Tagliavini, F.; Venneri, A.; Boccia, S.; Cagnin, A.; Calabro, G. E.; Bozzali, M.; Zuffi, M.; Zanusso, G.; Vista, M.; Vacca, A.; Tripi, G.; Tognoni, G.; Tiraboschi, P.; Sucapane, P.; Spallazzi, M.; Sibilia, G.; Sensi, S.; Rubino, E.; Rosso, M.; Roncacci, S.; Puccio, G.; Plutino, A.; Parnetti, L.; Pardini, M.; Parchi, P.; Orsini, A. V. M.; Musso, A. M.; Mura, G.; Monastero, R.; Moda, F.; Merlo, P.; Mei, D.; Mecocci, P.; Giuseppina Mascia, M.; Martorana, A.; Marti, A.; Marcon, M.; Malagu, S.; Luzzi, S.; Luiselli, D.; Luca, A.; Isella, V.; Imperiale, D.; Iavarone, A.; Guarino, M.; Gragnaniello, D.; Giubilei, F.; Forloni, G.; Floris, G.; Fiori, C.; Filippi, M.; Farina, E.; Fabi, K.; Esposito, S.; Di Giorgi, L.; Della Rocca, G.; De Togni, L.; Colao, R.; Ceci, M.; Capellari, S.; Canu, E. D. G.; Bessi, V.; Bellelli, G.; Baschi, R.; Babiloni, C.; Bagnato, S.; Arighi, A.; Arabia, G.; Angeloni, R.. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 46:7(2025), pp. 2913-2923. [10.1007/s10072-025-08143-5]
Towards a new Value-based scenario for the management of dementia in Italy: a SINdem delphi consensus study
Venneri A.;
2025-01-01
Abstract
Abstract: This national expert-based Delphi-consensus aims at formulating recommendations on the management of dementia care in Italy. This effort seems important and timely given in light of a new scenario arising from a new biological definition of Alzheimer’s disease (AD) and the availability of disease-modifying treatments (DMTs). Methods: the Steering Committee of the Italian Neurological Society for dementia (SINdem) created appropriate statements. Invited SINdem experts were requested to vote on the statements according to a modified three-round Delphi method. Only those statements reaching Grade A (full agreement ≥ 75%) or B (overall agreement ≥ 80% and full disagreement < 5%) were included in the final document. Round answers’ consistency was graded using the Cohen’s k and within-class correlation coefficient. Results: Forty-six experts voted on 20 statements, which focused on the following aspects: i) organization of care services from early diagnosis to the management of advanced clinical stages; ii) access to biomarkers for a biological diagnosis of AD; iii) requirements necessary for the administration of DMTs; iv) main actors and pathways for the management of patients suffering from cognitive disorders. At the end of the process, 4 statements (20%) received a Grade A consensus, while 16 (80%) reached a Grade B consensus. Although the responses reflect heterogeneity among Italian regions, there was a fair degree of consistency for all statements. Conclusion: The high strength of this expert-based Delphi-consensus may offer guidance for improving the patient’s journey of individuals with cognitive decline from a biological diagnosis to DMTs administration and may possibly offer hints to the Health Systems on dementia.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
