The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.
PGRS domain structures: Doomed to sail the mycomembrane / Berisio, R; Delogu, G. - In: PLOS PATHOGENS. - ISSN 1553-7366. - 18:9(2022), p. 1010760. [10.1371/journal.ppat.1010760]
PGRS domain structures: Doomed to sail the mycomembrane
Delogu G
2022-01-01
Abstract
The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.File in questo prodotto:
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