Vitamin D is increasingly recognized for its role in cardiovascular health beyond its well-established effects on bone metabolism. This review synthesizes findings from observational studies, interventional trials, and meta-analyses to clarify the mechanisms through which vitamin D impacts cardiovascular health, including its influence on vascular function, inflammation, and metabolic pathways. Additionally, this review emphasizes the importance of a personalized approach to vitamin D supplementation, integrating individual cardiovascular risk profiles, baseline vitamin D levels, and comorbid conditions, such as hypertension and diabetes. While current evidence supports the association between low vitamin D levels and increased cardiovascular mortality, this work contributes novel insights by proposing tailored strategies for supplementation, particularly for high-risk subgroups. Practical recommendations for implementing these strategies in clinical practice are also discussed, providing a framework for optimizing cardiovascular outcomes through individualized vitamin D management.
A Personalized Approach to Vitamin D Supplementation in Cardiovascular Health Beyond the Bone: An Expert Consensus by the Italian National Institute for Cardiovascular Research / Mattioli, Anna Vittoria; Coppi, Francesca; Severino, Paolo; Penna, Claudia; Pagliaro, Pasquale; Dei Cas, Alessandra; Bucciarelli, Valentina; Madonna, Rosalinda; Tarperi, Cantor; Schena, Federico; Cetrullo, Silvia; Angelone, Tommaso; Rocca, Carmine; Parenti, Astrid; Palazzuoli, Alberto; Margonato, Alberto; Paolillo, Stefania; Perrone Filardi, Pasquale; Barillà, Francesco; Lombardi, Carlo; Pinti, Marcello; Molinari, Claudio; Cevese, Antonio; Novo, Giuseppina; Pizzi, Carmine; Porto, Italo; Poggesi, Corrado; Gallina, Sabina; Ambrosio, Giuseppe; Fedele, Francesco; Null, Null. - In: NUTRIENTS. - ISSN 2072-6643. - 17:1(2024). [10.3390/nu17010115]
A Personalized Approach to Vitamin D Supplementation in Cardiovascular Health Beyond the Bone: An Expert Consensus by the Italian National Institute for Cardiovascular Research
Dei Cas, Alessandra;
2024-01-01
Abstract
Vitamin D is increasingly recognized for its role in cardiovascular health beyond its well-established effects on bone metabolism. This review synthesizes findings from observational studies, interventional trials, and meta-analyses to clarify the mechanisms through which vitamin D impacts cardiovascular health, including its influence on vascular function, inflammation, and metabolic pathways. Additionally, this review emphasizes the importance of a personalized approach to vitamin D supplementation, integrating individual cardiovascular risk profiles, baseline vitamin D levels, and comorbid conditions, such as hypertension and diabetes. While current evidence supports the association between low vitamin D levels and increased cardiovascular mortality, this work contributes novel insights by proposing tailored strategies for supplementation, particularly for high-risk subgroups. Practical recommendations for implementing these strategies in clinical practice are also discussed, providing a framework for optimizing cardiovascular outcomes through individualized vitamin D management.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.